Wdr72 - WD repeat domain 72 Gene

Mus musculus

Also known as D230040E23

Gene ID: 546144 | Gene type: protein coding

About Wdr72

Summary

Acts upstream of or within enamel mineralization; extracellular matrix disassembly; and protein localization to plasma membrane. Located in endosome and nucleus. Used to study amelogenesis imperfecta hypomaturation type 2A3. Human ortholog(s) of this gene implicated in amelogenesis imperfecta hypomaturation type 2A3. Orthologous to human WDR72 (WD repeat domain 72). [provided by Alliance of Genome Resources, Apr 2022]

Wdr72 Products(2)

mRNA	Protein	Name
NM_001033500.4	NP_001028672.2	WD repeat-containing protein 72 isoform 1
NM_001411342.1	NP_001398271.1	WD repeat-containing protein 72 isoform 2

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within ameloblast differentiation	IMP IMP: Inferred from mutant phenotype	35181734	MGI
acts upstream of or within amelogenesis	IMP IMP: Inferred from mutant phenotype	35181734	MGI
acts upstream of or within enamel mineralization	IMP IMP: Inferred from mutant phenotype	25008349	MGI
acts upstream of or within endocytosis	IMP IMP: Inferred from mutant phenotype	35181734	MGI
acts upstream of or within extracellular matrix disassembly	IMP IMP: Inferred from mutant phenotype	26247047	MGI
acts upstream of or within extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	35181734	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	35181734	MGI
acts upstream of or within microtubule polymerization	IMP IMP: Inferred from mutant phenotype	35181734	MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	35181734	MGI
acts upstream of or within protein import	IMP IMP: Inferred from mutant phenotype	35181734	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	35181734	MGI
acts upstream of or within protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	26247047	MGI
acts upstream of or within regulation of pH	IMP IMP: Inferred from mutant phenotype	35181734	MGI
acts upstream of or within ruffle organization	IMP IMP: Inferred from mutant phenotype	35181734	MGI
acts upstream of or within tubulin complex assembly	IMP IMP: Inferred from mutant phenotype	35181734	MGI
acts upstream of or within vesicle organization	IMP IMP: Inferred from mutant phenotype	35181734	MGI
acts upstream of or within vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	35181734	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in endosome	IDA IDA: Inferred from direct assay	25008349	MGI
located in nucleus	IDA IDA: Inferred from direct assay	31336344	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

WD repeat-containing protein 72

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15793	WDR72 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Wdr72	NCBI	NCBI:256764

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