TRMT10C - tRNA methyltransferase 10C, mitochondrial RNase P subunit Gene

Also Known as HNYA; MRPP1; COXPD30; RG9MTD1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54931

About TRMT10C

Cytogenetic location: 3q12.3 Genomic coordinates (GRCh38): 3:101,561,868-101,566,446 (from NCBI)

This gene has 2 transcripts (splice variants), 184 orthologues, 2 paralogues and is associated with 3 phenotypes. Ubiquitous expression in adrenal (RPKM 10.2), lymph node (RPKM 9.9) and 25 other tissues.

Summary

This gene encodes the precursor of a subunit of the mitochondrial ribonuclease P, which is involved in 5' processing of mitochondrial tRNAs. The encoded protein may confer RNA-binding capacity to mitochondrial ribonuclease P and may be essential for transcript processing, RNA modification, translation and mitochondrial respiration. [provided by RefSeq, Nov 2012]

TRMT10C Products (1)

mRNA Protein Name
NM_017819.4 NP_060289.2 tRNA methyltransferase 10 homolog C precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
29880640 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18984158 GOA
enables tRNA (adenine(9)-N1)-methyltransferase activity IDA
IDA: Inferred from direct assay
23042678 GOA
enables tRNA (guanosine(9)-N1)-methyltransferase activity IDA
IDA: Inferred from direct assay
23042678 GOA
enables tRNA binding IDA
IDA: Inferred from direct assay
29040705 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in mRNA processing IDA
IDA: Inferred from direct assay
29072297 GOA
involved in mitochondrial RNA 5'-end processing IMP
IMP: Inferred from mutant phenotype
21593607 GOA
involved in mitochondrial tRNA 3'-end processing IDA
IDA: Inferred from direct assay
29040705 GOA
involved in mitochondrial tRNA 5'-end processing IDA
IDA: Inferred from direct assay
29040705 GOA
involved in mitochondrial tRNA methylation IDA
IDA: Inferred from direct assay
23042678 GOA
involved in mitochondrial tRNA processing IMP
IMP: Inferred from mutant phenotype
27132592 GOA
involved in positive regulation of mitochondrial translation IMP
IMP: Inferred from mutant phenotype
27132592 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in mitochondrial nucleoid IDA
IDA: Inferred from direct assay
24703694 GOA
part of mitochondrial ribonuclease P complex IPI
IPI: Inferred from physical interaction
29880640 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
23042678 GOA
located in mitochondrion IMP
IMP: Inferred from mutant phenotype
27132592 GOA
part of tRNA methyltransferase complex IPI
IPI: Inferred from physical interaction
23042678 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRMT10C Protein Structure

tRNA_m1G_MT

tRNA_m1G_MT: tRNA (Guanine-1)-methyltransferase (214 - 380)

  • 0
  • 100
  • 200
  • 300
  • 403 a.a.
Protein Preferred Names Protein Names

tRNA methyltransferase 10 homolog C

  • HBV pre-S2 trans-regulated protein 2

TRMT10C Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
TRMT10C Q7L0Y3 HSD17B10 Homo sapiens Q99714
Anti Tag CoIP
18984158
Intra
TRMT10C Q7L0Y3 PRORP Homo sapiens O15091
Anti Tag CoIP
18984158
Intra
TRMT10C Q7L0Y3 HSD17B10 Homo sapiens Q99714
Methyltransferase Ass
29880640
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Combined Oxidative Phosphorylation Deficiency 30

  • COXPD30

  • Combined Oxidative Phosphorylation Defect Type 30

  • Combined Oxidative Phosphorylation Deficiency, Type 30
Mitochondrial Disease

  • Mitochondrial Diseases

  • Mitochondrial Disorder
Combined Oxidative Phosphorylation Deficiency 6

  • Severe X-Linked Mitochondrial Encephalomyopathy

  • COXPD6

  • Mitochondrial Encephalomyopathy Due To Combined Oxidative Phosphorylation Defect 6

  • Mitochondrial Encephalomyopathy Due To Coxpd6

  • Encephalomyopathy, Mitochondrial, X-Linked

  • Encephalomyopathy Mitochondrial X-Linked

  • Oxidative Phosphorylation Deficiency, Combined, Type 6
Alpha-Aminoadipic And Alpha-Ketoadipic Aciduria

  • 2-Aminoadipic 2-Oxoadipic Aciduria

  • Amoxad

  • AAKAD

  • 2-Ketoadipic Aciduria

  • Alpha-Aminoadipic Aciduria

  • Amino Adipic Aciduria

  • Aciduria, 2-Aminoadipic 2-Oxoadipic
Lactic Acidosis

  • Acidosis, Lactic

  • Acidosis Lactic
Respiratory Failure

  • Acute Respiratory Failure

  • Chronic Respiratory Failure

  • Respiratory Insufficiency

  • Acute-On-Chronic Respiratory Failure

  • Respiratory Disease

  • Acute And Chronic Respiratory Failure

  • Respiratory Insufficiency/Failure

  • Chronic Respiratory Disease

  • Pulmonary Valve Insufficiency

  • Chronic Disease Of Respiratory System

  • Respiration Disorders

  • Respiratory Tract Diseases

  • Lung Failure Nos

  • Pulmonary Failure

  • Arf - [Acute Respiratory Failure]

  • Acute Respiratory Insufficiency

  • Acute Pulmonary Insufficiency

  • Acute Respiration Failure

  • Chronic Respiration Failure
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS15088 TRMT10C Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TRMT10C RGD RGD:1306333
Macaca mulatta TRMT10C VGNC VGNC:79569
Bos taurus TRMT10C VGNC VGNC:36367
Mus musculus TRMT10C MGD MGI:1196261
Felis catus TRMT10C VGNC VGNC:66567
Canis familiaris TRMT10C VGNC VGNC:47853
Others TRMT10C NCBI