SOBP - sine oculis binding protein homolog Gene

Also Known as JXC1; MRAMS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55084

About SOBP

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:107,490,117-107,661,306 (from NCBI)

This gene has 4 transcripts (splice variants), 205 orthologues, 1 paralogue and is associated with 3 phenotypes. Broad expression in brain (RPKM 6.2), ovary (RPKM 3.5) and 21 other tissues.

Summary

The protein encoded by this gene is a nuclear Zinc Finger Protein that is involved in development of the cochlea. Defects in this gene have also been linked to intellectual disability. [provided by RefSeq, Mar 2011]

SOBP Products (1)

mRNA	Protein	Name
NM_018013.4	NP_060483.3	sine oculis-binding protein homolog

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	References	Source
involved in cognition	IMP IMP: Inferred from mutant phenotype	21035105	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SOBP Protein Structure

SOBP

0
200
400
600
800
873 a.a.

Protein Preferred Names	Protein Names
sine oculis-binding protein homolog	jackson circler protein 1

Related Diseases

Diseases	Alias
Mental Retardation, Anterior Maxillary Protrusion, And Strabismus	Intellectual Disability, Anterior Maxillary Protrusion, And Strabismus MRAMS Anterior Maxillary Protrusion-Strabismus-Intellectual Disability Syndrome Mrams Syndrome
Deafness, Autosomal Recessive 62	DFNB62 Autosomal Recessive Nonsyndromic Deafness 62 Autosomal Recessive Deafness 62
Esotropia	Convergence In Manifest Squint Crossed Eyes Internal Strabismus Convergent Concomitant Strabismus Convergent Squint Convergent Strabismus Cross-Eye
Amblyopia	Lazy Eye
Spermatocytoma	Spermatocytic Seminoma
Strabismus	Strabismus, Susceptibility To Strabismus, Susceptibility To, 1 Strabismus 1
Branchiootorenal Syndrome	Branchio-Oto-Renal Syndrome Bor Syndrome Branchiootorenal Dysplasia Melnick-Fraser Syndrome Branchiootorenal Spectrum Disorders Branchio-Otorenal Dysplasia Branchio Oto Renal Syndrome Branchiootorenal/Branchiootic Syndrome Bo Syndrome Bor Bos Branchio-Otorenal Syndrome Branchiootic Syndrome Branchiootorenal Syndrome Branchiootic Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16776A	(2S,5S)-Censavudine		98.12%	Unkown
HY-RS13551	SOBP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SOBP	VGNC	VGNC:49867
Mus musculus	SOBP	MGD	MGI:1924427
Rattus norvegicus	SOBP	RGD	RGD:1560479
Macaca mulatta	SOBP	VGNC	VGNC:77790
Bos taurus	SOBP	VGNC	VGNC:35118
Felis catus	SOBP	VGNC	VGNC:102522