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ANKZF1 - ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 Gene

Also Known as Vms1; ZNF744

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55139

About ANKZF1

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:219,229,806-219,236,679 (from NCBI)

This gene has 26 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in lymph node (RPKM 19.0), spleen (RPKM 18.7) and 25 other tissues.

Summary

Predicted to enable metal ion binding activity. Involved in cellular response to hydrogen peroxide. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ANKZF1 Products (3)

mRNA	Protein	Name
NM_001042410.2	NP_001035869.1	ankyrin repeat and zinc finger domain-containing protein 1 isoform 1
NM_001282792.2	NP_001269721.1	ankyrin repeat and zinc finger domain-containing protein 1 isoform 2
NM_018089.3	NP_060559.2	ankyrin repeat and zinc finger domain-containing protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA endonuclease activity	IDA IDA: Inferred from direct assay	30244831	GOA
enables catalytic activity, acting on a tRNA	IDA IDA: Inferred from direct assay	30244831	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22190034	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	28302725	GOA
involved in protein quality control for misfolded or incompletely synthesized proteins	IDA IDA: Inferred from direct assay	29632312	GOA
involved in rescue of stalled ribosome	IDA IDA: Inferred from direct assay	29632312	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	28302725	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANKZF1 Protein Structure

Ank

0
200
400
600
726 a.a.

Protein Preferred Names	Protein Names
ankyrin repeat and zinc finger domain-containing protein 1	ankyrin repeat and zinc finger domain containing 1

ANKZF1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89633	ANKZF1 Antibody (YA8977)	WB, ICC/IF, IF-Tissue, IP, ELISA	human

Related Diseases

Diseases	Alias
Immunodeficiency 40	Dock2 Deficiency IMD40 Immunodeficiency, Type 40
Charcot-Marie-Tooth Disease, Axonal, Type 2e	Charcot-Marie-Tooth Disease Type 2 CMT2E CMT2S CMT2Y Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease Axonal Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2s Charcot-Marie-Tooth Disease, Type 2e Hereditary Motor And Sensory Neuropathy Type 2 Charcot-Marie-Tooth Neuropathy, Type 2s Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2y Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y Charcot-Marie-Tooth Neuropathy, Type 2y Charcot-Marie-Tooth Disease, Type 2y Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Neuropathy Type 2e Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation Cmt2 Due To Vcp Mutation Charcot-Marie-Tooth Disease Type 2s Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Cmt2 Charcot-Marie-Tooth Neuropathy, Type 2e Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type Hereditary Motor And Sensory Neuropathy Okinawa Type Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y Charcot-Marie-Tooth Neuropathy Type 2y Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s Charcot-Marie-Tooth Neuropathy Type 2s Charcot-Marie-Tooth Type 2 Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease 2e Charcot-Marie-Tooth Disease Axonal Type 2e Charcot-Marie-Tooth Disease Neuronal Type 2e Charcot-Marie-Tooth Disease 2s Charcot-Marie-Tooth Neuropathy Axonal Type 2s Charcot-Marie-Tooth Disease 2y Charcot-Marie-Tooth Disease, Type 2 Hereditary Motor And Sensory-Neuropathy Type Ii
Non-Syndromic X-Linked Intellectual Disability	X-Linked Non-Syndromic Intellectual Disability Non-Specific X-Linked Mental Retardation X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00738	ANKZF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ANKZF1	VGNC	VGNC:69697
Rattus norvegicus	ANKZF1	RGD	RGD:1359242
Felis catus	ANKZF1	VGNC	VGNC:59825
Mus musculus	ANKZF1	MGD	MGI:1098746
Canis familiaris	ANKZF1	VGNC	VGNC:37921
Bos taurus	ANKZF1	VGNC	VGNC:25949