SEC61A2 - SEC61 translocon subunit alpha 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55176

Summary

The protein encoded by this gene has similarity to a mouse protein which suggests a role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. It may also be required for the assembly of membrane and secretory proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Broad expression in brain (RPKM 12.8), testis (RPKM 10.0) and 24 other tissues.

SEC61A2 Products (3)

mRNA Protein Name
NM_001142627.3 NP_001136099.1 protein transport protein Sec61 subunit alpha isoform 2 isoform c
NM_001142628.1 NP_001136100.1 protein transport protein Sec61 subunit alpha isoform 2 isoform b
NM_018144.4 NP_060614.2 protein transport protein Sec61 subunit alpha isoform 2 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
30021884 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEC61A2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SEC61A2 Q9H9S3 SEC61B Homo sapiens P60468
Crosslink
30021884
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-139616 Sec61-IN-2 Inhibitor 99.24% Unkown