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PRH2 - proline rich protein HaeIII subfamily 2 Gene

Also Known as Pr; pr1/Pr2; PRP-1/PRP-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5555

About PRH2

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,929,236-10,934,845 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 10 orthologues and 6 paralogues. Restricted expression toward salivary gland (RPKM 6639.8).

Summary

This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. In western population this locus is commonly biallelic and encodes proline-rich protein (PRP) isoforms, PRP-1 and PRP-2. The reference genome encodes the PRP-1 allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Oct 2015]

PRH2 Products (1)

mRNA	Protein	Name
NM_001110213.1	NP_001103683.1	salivary acidic proline-rich phosphoprotein 1月2日 preproprotein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16203048	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRH2 Protein Structure

Pro-rich

0
100
166 a.a.

Protein Preferred Names	Protein Names
salivary acidic proline-rich phosphoprotein 1/2	acidic salivary proline-rich protein, HaeIII type, 2

Related Diseases

Diseases	Alias
Dental Caries	Dental Caries Extending Into Pulp Dental Caries Of Smooth Surface Dental Caries Pit And Fissure Smooth Surface Dental Caries Dental Decay Carious Teeth Dental Cavity Saprodontia Teeth Decayed Tooth Caries Tooth Decay
Retinitis Pigmentosa 35	RP35 Retinitis Pigmentosa-35 Retinitis Pigmentosa, Type 35
Ulna And Fibula, Absence Of, With Severe Limb Deficiency	Schinzel Phocomelia Syndrome Aarrs Limb/Pelvis-Hypoplasia/Aplasia Syndrome LPHAS Schinzel Type Phocomelia Absence Of Ulna And Fibula With Severe Limb Deficiency Al-Awadi/Raas-Rothschild Syndrome Al Awadi-Raas-Rothschild Syndrome Al-Awadi/Raas-Rothschild/Schinzel Phocomelia Syndrome Aplasia/Hypoplasia Of Limbs And Pelvis Congenital Absence Of Ulna And Fibula Severe Limb Deficit Phocomelia, Schinzel Type Al-Awadi-Raas-Rothschild Syndrome Ulna And Fibula Absence Of With Severe Limb Deficiency Limb Pelvis Hypoplasia Aplasia Syndrome Limb/Pelvis/Uterus-Hypoplasia/Aplasia Syndrome Ulna And Fibula, Absence Of, With Sever Limb Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11091	PRH1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11092	PRH2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown