KIF27 - kinesin family member 27 Gene

Homo sapiens

Gene ID: 55582 | Gene type: protein coding

About KIF27

Cytogenetic location: 9q21.32 Genomic coordinates (GRCh38): 9:83,834,099-83,921,432 (from NCBI)

This gene has 5 transcripts (splice variants), 216 orthologues and 41 paralogues. Broad expression in testis (RPKM 7.5), thyroid (RPKM 3.1) and 21 other tissues.

Summary

This gene is a member of the KIF27 (Kinesin 4) sub-family of the mammalian Kinesin family. The gene is an ortholog of the Drosophila Cos2 gene, which plays an important role in the Hedgehog signaling pathway. The encoded protein contains an N-terminal motor domain which includes nucleotide-binding and microtubule-interacting regions, a stalk domain containing a predicted coiled coil motif and a C-terminal tail domain. Alternatively spliced transcript variants have been observed for this gene. Pseudogenes associated with this gene are located on chromosome 9. [provided by RefSeq, Dec 2012]

KIF27 Products(6)

mRNA	Protein	Name
NM_001271927.3	NP_001258856.1	kinesin-like protein KIF27 isoform B
NM_001271928.3	NP_001258857.1	kinesin-like protein KIF27 isoform C
NM_001354069.2	NP_001340998.1	kinesin-like protein KIF27 isoform D
NM_001354070.2	NP_001340999.1	kinesin-like protein KIF27 isoform E
NM_001354071.2	NP_001341000.1	kinesin-like protein KIF27 isoform F
NM_017576.4	NP_060046.1	kinesin-like protein KIF27 isoform A

KIF27 Protein Structure

Kinesin

0
300
600
900
1200
1401 a.a.

Protein Preferred Names

Protein Names

kinesin-like protein KIF27

Related Diseases

Diseases

Alias

Childhood Infratentorial Ependymoma

Pediatric Infratentorial Ependymoma

Acrocallosal Syndrome

ACLS	Schinzel Acrocallosal Syndrome
Joubert Syndrome 12	Schinzel Syndrome 1
Acrocallosal Syndrome, Schinzel Type	Hallux Duplication, Postaxial Polydactyly, And Absence Of Corpus Callosum
Acs	Absence Of Corpus Callosum With Unusual Facial Appearance, Mental Deficiency, Duplication Of The Halluces And Polydactyly
Hallux Duplication Postaxial Polydactyly And Absence Of Corpus Callosum	JBTS12
Acrocallosal Syndrome

Congenital Fibrosis Of The Extraocular Muscles

Congenital Fibrosis Of Extraocular Muscles	Cfeom
Feom	Congenital External Ophthalmoplegia
Congenital Fibrosis Syndrome	General Fibrosis Syndrome

Megabladder, Congenital

MGBL	Congenital Megabladder

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07281	KIF27 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	KIF27	VGNC	VGNC:30598
Macaca mulatta	KIF27	VGNC	VGNC:73851
Rattus norvegicus	KIF27	RGD	RGD:621071
Mus musculus	KIF27	MGD	MGI:1922300
Canis familiaris	KIF27	VGNC	VGNC:42401
Felis catus	KIF27	VGNC	VGNC:63117

Name
Email *

	Sorry, but the email address you supplied was invalid.