KIF27 - kinesin family member 27 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55582

About KIF27

Cytogenetic location: 9q21.32 Genomic coordinates (GRCh38): 9:83,834,099-83,921,432 (from NCBI)

This gene has 5 transcripts (splice variants), 216 orthologues and 41 paralogues. Broad expression in testis (RPKM 7.5), thyroid (RPKM 3.1) and 21 other tissues.

Summary

This gene is a member of the KIF27 (Kinesin 4) sub-family of the mammalian Kinesin family. The gene is an ortholog of the Drosophila Cos2 gene, which plays an important role in the Hedgehog signaling pathway. The encoded protein contains an N-terminal motor domain which includes nucleotide-binding and microtubule-interacting regions, a stalk domain containing a predicted coiled coil motif and a C-terminal tail domain. Alternatively spliced transcript variants have been observed for this gene. Pseudogenes associated with this gene are located on chromosome 9. [provided by RefSeq, Dec 2012]

KIF27 Products (6)

mRNA	Protein	Name
NM_001271927.3	NP_001258856.1	kinesin-like protein KIF27 isoform B
NM_001271928.3	NP_001258857.1	kinesin-like protein KIF27 isoform C
NM_001354069.2	NP_001340998.1	kinesin-like protein KIF27 isoform D
NM_001354070.2	NP_001340999.1	kinesin-like protein KIF27 isoform E
NM_001354071.2	NP_001341000.1	kinesin-like protein KIF27 isoform F
NM_017576.4	NP_060046.1	kinesin-like protein KIF27 isoform A

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIF27 Protein Structure

Kinesin

0
300
600
900
1200
1401 a.a.

Protein Preferred Names	Protein Names
kinesin-like protein KIF27

KIF27 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KIF27	Q86VH2	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	32296183
Intra	KIF27	Q86VH2	MAGEA6	Homo sapiens	P43360	Y2H Array	32296183
Intra	KIF27	Q86VH2	MAGEA3	Homo sapiens	P43357	Y2H Prey Pooling	32296183
Intra	KIF27	Q86VH2	MAGEA3	Homo sapiens	P43357	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Childhood Infratentorial Ependymoma	Pediatric Infratentorial Ependymoma
Acrocallosal Syndrome	ACLS Schinzel Acrocallosal Syndrome Joubert Syndrome 12 Schinzel Syndrome 1 Acrocallosal Syndrome, Schinzel Type Hallux Duplication, Postaxial Polydactyly, And Absence Of Corpus Callosum Acs Absence Of Corpus Callosum With Unusual Facial Appearance, Mental Deficiency, Duplication Of The Halluces And Polydactyly Hallux Duplication Postaxial Polydactyly And Absence Of Corpus Callosum JBTS12 Acrocallosal Syndrome
Congenital Fibrosis Of The Extraocular Muscles	Congenital Fibrosis Of Extraocular Muscles Cfeom Feom Congenital External Ophthalmoplegia Congenital Fibrosis Syndrome General Fibrosis Syndrome
Megabladder, Congenital	MGBL Congenital Megabladder
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07281	KIF27 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	KIF27	VGNC	VGNC:30598
Macaca mulatta	KIF27	VGNC	VGNC:73851
Rattus norvegicus	KIF27	RGD	RGD:621071
Mus musculus	KIF27	MGD	MGI:1922300
Canis familiaris	KIF27	VGNC	VGNC:42401
Felis catus	KIF27	VGNC	VGNC:63117
Others	KIF27	NCBI