TENM3 - teneurin transmembrane protein 3 Gene

Also Known as ODZ3; TEN3; TNM3; ten-3; Ten-m3; MCOPCB9; MCOPS15

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55714

About TENM3

Cytogenetic location: 4q34.3-q35.1 Genomic coordinates (GRCh38): 4:181,447,613-182,803,024 (from NCBI)

This gene has 6 transcripts (splice variants), 327 orthologues, 4 paralogues and is associated with 3 phenotypes. Broad expression in placenta (RPKM 7.1), brain (RPKM 4.3) and 14 other tissues.

Summary

This gene encodes a large transmembrane protein that may be involved in the regulation of neuronal development. Mutation in this gene causes microphthalmia. [provided by RefSeq, Aug 2015]

TENM3 Products (1)

mRNA	Protein	Name
NM_001080477.4	NP_001073946.1	teneurin-3

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	References	Source
involved in camera-type eye morphogenesis	IMP IMP: Inferred from mutant phenotype	22766609	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TENM3 Protein Structure

Ten_N

Tox-GHH

0
500
1000
1500
2000
2500
2699 a.a.

Protein Preferred Names	Protein Names
teneurin-3	ODZ3-like protein

Related Diseases

Diseases	Alias
Microphthalmia, Isolated, With Coloboma 9	MCOPCB9 Microphthalmia, Syndromic 15 Microphthalmia, Isolated, With Coloboma, 9 Isolated Colobomatous Microphthalmia 9 Microphthalmia, Syndromic, 15 MCOPS15 Microphthalmia And/Or Coloboma With Developmental Delay Microphthalmia, Isolated, With Coloboma, Type 9
Colobomatous Microphthalmia	Anophthalmia-Microphthalmia Syndrome Mac Microphthalmia With Colobomatous Cyst Microphthalmia-Anophthalmia-Coloboma Syndrome Microphthalmia-Anophthalmia-Coloboma Microphthalmia And Mental Deficiency
Microphthalmia	Microphthalmos Isolated Anophthalmia-Microphthalmia Syndrome Isolated Microphthalmia-Anophthalmia-Coloboma Simple Microphthalmos Clinical Anophthalmia Isolated Anophthalmia - Microphthalmia Isolated Pure Microphthalmia Mac Spectrum Microphthalmia-Anophthalmia-Coloboma Spectrum Primitive Anophthalmia Globe Of Eye Small Small Eyeball Hypoplasia Of Eye Isolated Nanophthalmos Rudimentary Eye Dysplasia Of Eye
Sclerocornea	Isolated Congenital Sclerocornea
Spinocerebellar Ataxia, Autosomal Recessive 12	Autosomal Recessive Spinocerebellar Ataxia 12 SCAR12 Spinocerebellar Ataxia With Mental Retardation And Epilepsy Autosomal Recessive Cerebellar Ataxia-Epilepsy-Intellectual Disability Syndrome Due To Wwox Deficiency Autosomal Recessive Spinocerebellar Ataxia Type 12 Spinocerebellar Ataxia, Autosomal Recessive, 12 Ataxia, Spinocerebellar, Autosomal Recessive, Type 12
Anterior Segment Dysgenesis	Anterior Segment Developmental Anomaly Anterior Segment Mesenchymal Dysgenesis Corneal Opacification And Other Ocular Anomalies Sclerocornea With Other Ocular Anomalies Asmd Asod Anterior Segment Ocular Dysgenesis Foxe3-Related Ocular Disorder Familial Ocular Anterior Segment Mesenchymal Dysgenesis Dysgenesis, Anterior Segment Irido-Corneal Dysgenesis Axenfeld-Rieger Syndrome, Type 3
Intellectual Developmental Disorder, X-Linked, Syndromic, Wilson-Turner Type	Wilson-Turner Syndrome WTS Mrxs6 X-Linked Intellectual Disability-Gynecomastia-Obesity Syndrome Mrxswt Wilson-Turner X-Linked Mental Retardation Syndrome Mental Retardation, X-Linked, Syndromic 6 Mental Retardation, X-Linked, With Gynecomastia And Obesity Intellectual Disability, X-Linked, Syndromic 6 Intellectual Disability, X-Linked, With Gynecomastia And Obesity Wilson Turner Intellectual Disability Syndrome X-Linked Intellectual Disability - Gynecomastia - Obesity
Ptosis	Blepharoptosis Drooping Eyelid Droopy Eyelid Ptosis Of Eyelid Paralysis Of Levator Palpebrae Superioris
Syndromic X-Linked Intellectual Disability	X-Linked Syndromic Intellectual Disability
Coloboma Of Macula	Coloboma Congenital Ocular Coloboma Microphthalmia, Isolated, With Coloboma Agenesis Of Macula Hereditary Macular Coloboma Ocular Coloboma Coloboma Of Eye Macular Coloboma Uveoretinal Coloboma
Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14364	TENM3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TENM3	MGD	MGI:1345183
Macaca mulatta	TENM3	VGNC	VGNC:100277
Felis catus	TENM3	VGNC	VGNC:66071
Rattus norvegicus	TENM3	RGD	RGD:1306641
Canis familiaris	TENM3	VGNC	VGNC:47248
Bos taurus	TENM3	VGNC	VGNC:35743