PRKG2 - protein kinase cGMP-dependent 2 Gene

Also Known as AMD4; PKG2; SMDP; cGK2; cGKII; PRKGR2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5593

About PRKG2

Cytogenetic location: 4q21.21 Genomic coordinates (GRCh38): 4:81,087,370-81,217,836 (from NCBI)

This gene has 7 transcripts (splice variants), 185 orthologues, 5 paralogues and is associated with 3 phenotypes. Biased expression in prostate (RPKM 4.2), small intestine (RPKM 4.1) and 11 other tissues.

Summary

This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein binds to and inhibits the activation of several Receptor Tyrosine Kinases. The membrane-bound protein is a regulator of intestinal secretion, bone growth and Renin secretion. Alternate splicing results in multiple transcript variants encoding distinct isoforms whose regulatory N-termini differ in length but whose C-terminal catalytic domains are identical. [provided by RefSeq, May 2018]

PRKG2 Products (7)

mRNA	Protein	Name
NM_001282480.1	NP_001269409.1	cGMP-dependent protein kinase 2 isoform b
NM_001282481.1	NP_001269410.1	cGMP-dependent protein kinase 2 isoform b
NM_001282482.1	NP_001269411.1	cGMP-dependent protein kinase 2 isoform c
NM_001282483.1	NP_001269412.1	cGMP-dependent protein kinase 2 isoform d
NM_001282485.2	NP_001269414.1	cGMP-dependent protein kinase 2 isoform e
NM_001363401.2	NP_001350330.1	cGMP-dependent protein kinase 2 isoform a
NM_006259.3	NP_006250.1	cGMP-dependent protein kinase 2 isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables cGMP-dependent protein kinase activity	IMP IMP: Inferred from mutant phenotype	33106379	GOA
enables mitogen-activated protein kinase binding	IMP IMP: Inferred from mutant phenotype	33106379	GOA
enables protein serine kinase activity	IMP IMP: Inferred from mutant phenotype	33106379	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	15905169	GOA
involved in signal transduction	IMP IMP: Inferred from mutant phenotype	33106379	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKG2 Protein Structure

cNMP_binding

Pkinase

0
200
400
600
762 a.a.

Protein Preferred Names	Protein Names
cGMP-dependent protein kinase 2	cGMP-dependent protein kinase II

PRKG2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89814	cGKII Antibody (YA9158)	WB, ICC/IF, IF-Tissue, IP, ELISA	human

Related Diseases

Diseases	Alias
Spondylometaphyseal Dysplasia, Pagnamenta Type	SMDP Dysplasia, Spondylometaphyseal, Pagnamenta Type
Acromesomelic Dysplasia 4	AMD4 Acromesomelic Dysplasia-4 Dysplasia, Acromesomelic, Type 4
Acromesomelic Dysplasia	Acromesomelic Dwarfism Dysplasia, Acromesomelic Acromesomelic Dysplasia Hunter-Thompson Type
Chromosome 4q21 Deletion Syndrome	4q21 Microdeletion Syndrome Monosomy 4q21 Del(4)(Q21) Chromosome Deletion Syndrome 4q21
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Hyperphenylalaninemia	Hyperphenylalaninaemia
Brachydactyly
Malignant Hemangioma
Secretory Diarrhea
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Alcohol Dependence, Protection Against Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic
Osteochondrodysplasia	Skeletal Dysplasia Chondrodystrophy Congenital Anomaly Of Cartilage Osteochondrodysplasias Cartilage Development Disorder Osteochondrodysplasia Syndrome Dysplasia, Skeletal Mucopolysaccharidosis Iv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11155	PRKG2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PRKG2	VGNC	VGNC:44990
Mus musculus	PRKG2	MGD	MGI:108173
Macaca mulatta	PRKG2	VGNC	VGNC:76420
Bos taurus	PRKG2	VGNC	VGNC:33341
Rattus norvegicus	PRKG2	RGD	RGD:3401
Felis catus	PRKG2	VGNC	VGNC:69070
Others	PRKG2	NCBI