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BAIAP2L1 - BAR/IMD domain containing adaptor protein 2 like 1 Gene

Also Known as IRTKS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55971

About BAIAP2L1

Cytogenetic location: 7q21.3-q22.1 Genomic coordinates (GRCh38): 7:98,291,650-98,401,090 (from NCBI)

This gene has 5 transcripts (splice variants), 277 orthologues and 2 paralogues. Broad expression in stomach (RPKM 26.9), colon (RPKM 14.1) and 19 other tissues.

Summary

This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for Insulin Receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin Cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. [provided by RefSeq, Oct 2009]

BAIAP2L1 Products (1)

mRNA	Protein	Name
NM_018842.5	NP_061330.2	brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables proline-rich region binding	IDA IDA: Inferred from direct assay	21098279	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21098279	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of actin filament polymerization	IDA IDA: Inferred from direct assay	21098279	GOA
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	19366662	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with actin cytoskeleton	IDA IDA: Inferred from direct assay	19366662	GOA
located in cytosol	IDA IDA: Inferred from direct assay	19366662	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BAIAP2L1 Protein Structure

IMD

SH3_9

0
100
200
300
400
511 a.a.

Protein Preferred Names	Protein Names
brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1	BAI1 associated protein 2 like 1

BAIAP2L1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	BAIAP2L1	Q9UHR4	espF(U)	Escherichia coli O157:H7	P0DJ89	ITC	21098279
Cross	BAIAP2L1	Q9UHR4	espF(U)	Escherichia coli O157:H7	P0DJ89	Peptide Array	21098279
Cross	BAIAP2L1	Q9UHR4	espF(U)	Escherichia coli O157:H7	P0DJ89	ITC	22921828
Cross	BAIAP2L1	Q9UHR4	espF(U)	Escherichia coli O157:H7	P0DJ89	Y2H	22921828
Cross	BAIAP2L1	Q9UHR4	espF(U)	Escherichia coli O157:H7	P0DJ89	NMR	21098279
Cross	BAIAP2L1	Q9UHR4	espF(U)	Escherichia coli O157:H7	P0DJ89	NMR	22921828
Intra	BAIAP2L1	Q9UHR4	EPS8	Homo sapiens	Q12929	NMR	22921828
Intra	BAIAP2L1	Q9UHR4	EPS8	Homo sapiens	Q12929	Pull Down	22921828
Intra	BAIAP2L1	Q9UHR4	EPS8	Homo sapiens	Q12929	ITC	22921828
Intra	BAIAP2L1	Q9UHR4	EPS8	Homo sapiens	Q12929	Peptide Array	21098279
Intra	BAIAP2L1	Q9UHR4	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	BAIAP2L1	Q9UHR4	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	BAIAP2L1	Q9UHR4	BAIAP2	Homo sapiens	Q9UQB8	Anti Tag CoIP	35271311
Intra	BAIAP2L1	Q9UHR4	BAIAP2	Homo sapiens	Q9UQB8-6	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Dentatorubral-Pallidoluysian Atrophy	DRPLA Naito-Oyanagi Disease Haw River Syndrome Myoclonic Epilepsy With Choreoathetosis Nod Ataxia, Chorea, Seizures, And Dementia Dentatorubropallidoluysian Atrophy Hrs Naito Oyanagi Disease Dentatorubral Pallidoluysian Atrophy Dentatorubro-Pallidoluysian Atrophy Myoclonic Epilepsies, Progressive Atrophy, Pallidoluysian, Dentatorubral
Donohue Syndrome	Leprechaunism Leprechaunism Syndrome Donohue'S Syndrome LEPRCH
Acanthosis Nigricans	Keratosis Nigricans An
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Hypogonadotropic Hypogonadism 6 With Or Without Anosmia	HH6 Kallmann Syndrome 6 Kal6 Hypogonadotropic Hypogonadism, Type 6 With/Without Anosmia
Gestational Diabetes	Gestational Diabetes Mellitus GDM Diabetes Mellitus Arising In Pregnancy Maternal Gestational Diabetes Mellitus Diabetes Mellitus, Gestational Diabetes Mellitus, Pregnancy Related Diabetes, Pregnancy-Induced Diabetes Gestational Diabetes, Gestational Diabetes Of Pregnancy Gdm - [Gestational Diabetes Mellitus] Gestational Diabetes Mellitus Nos Gestational Diabetes Complicating Pregnancy, Childbirth, Or The Puerperium

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01354	BAIAP2L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	BAIAP2L1	VGNC	VGNC:70109
Felis catus	BAIAP2L1	VGNC	VGNC:60071
Rattus norvegicus	BAIAP2L1	RGD	RGD:1308452
Mus musculus	BAIAP2L1	MGD	MGI:1914148
Bos taurus	BAIAP2L1	VGNC	VGNC:26413
Canis familiaris	BAIAP2L1	VGNC	VGNC:38372
Others	BAIAP2L1	NCBI