Cldn14 - claudin 14 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56173

Summary

This gene encodes a member of the Claudin family of tight junction proteins. The encoded protein is an integral membrane protein that may function in maintaining apical membrane polarization in tight junctions located between outer hair cells and supporting cells. Loss of function of this gene is associated with hearing problems. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Cldn14 Products (3)

mRNA Protein Name
NM_001165925.1 NP_001159397.1 claudin-14
NM_001165926.1 NP_001159398.1 claudin-14
NM_019500.4 NP_062373.3 claudin-14

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22373575 MGI
Cellular Component GO Annotation Evidence References Source
located in bicellular tight junction IDA
IDA: Inferred from direct assay
17130295 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
17130295 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

claudin-14

Cldn14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Cldn14 Q9Z0S3 CLDN16 Homo sapiens Q9Y5I7
Y2H
22373575
Cross
Cldn14 Q9Z0S3 CLDN16 Homo sapiens Q9Y5I7
Anti Bait CoIP
22373575
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02765 CLDN14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cldn14 NCBI NCBI:23562