SLC2A9 - solute carrier family 2 member 9 Gene

Also Known as GLUT9; GLUTX; UAQTL2; URATv1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 56606

About SLC2A9

Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:9,771,025-10,040,270 (from NCBI)

This gene has 13 transcripts (splice variants), 296 orthologues, 13 paralogues and is associated with 2 phenotypes. Broad expression in kidney (RPKM 4.4), liver (RPKM 1.6) and 18 other tissues.

Summary

This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

SLC2A9 Products (2)

mRNA	Protein	Name
NM_001001290.2	NP_001001290.1	solute carrier family 2, facilitated glucose transporter member 9 isoform 2
NM_020041.3	NP_064425.2	solute carrier family 2, facilitated glucose transporter member 9 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
NOT enables D-glucose transmembrane transporter activity	IDA IDA: Inferred from direct assay	28083649	GOA
enables D-glucose transmembrane transporter activity	IDA IDA: Inferred from direct assay	18842065	GOA
NOT enables fructose transmembrane transporter activity	IDA IDA: Inferred from direct assay	28083649	GOA
enables fructose transmembrane transporter activity	IDA IDA: Inferred from direct assay	18842065	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	31695625	GOA
enables urate transmembrane transporter activity	IDA IDA: Inferred from direct assay	18327257	GOA

Biological Process GO Annotation	Evidence	References	Source
NOT involved in D-glucose transmembrane transport	IDA IDA: Inferred from direct assay	28083649	GOA
involved in D-glucose transmembrane transport	IDA IDA: Inferred from direct assay	18842065	GOA
NOT involved in fructose transmembrane transport	IDA IDA: Inferred from direct assay	28083649	GOA
involved in fructose transmembrane transport	IDA IDA: Inferred from direct assay	18842065	GOA
involved in urate metabolic process	IMP IMP: Inferred from mutant phenotype	18834626	GOA
involved in urate transport	IDA IDA: Inferred from direct assay	18842065	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	28083649	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC2A9 Protein Structure

Sugar_tr

0
100
200
300
400
500
540 a.a.

Protein Preferred Names	Protein Names
solute carrier family 2, facilitated glucose transporter member 9	GLUT-9

Related Diseases

Diseases	Alias
Hypouricemia, Renal, 2	RHUC2 Uric Acid Concentration, Serum, Qtl 2 Hypouricemia Renal 2 Hypouricemia, Renal, Type 2
Hypouricemia, Renal, 1	Dalmatian Hypouricemia Renal Hypouricemia Hypouricemia, Renal Familial Renal Hypouricemia RHUC1 Hereditary Renal Hypouricemia Familial Renal Hypouricaemia Rhuc Hypouricemia Renal 1 Hypouricemia, Renal, Type 1
Nephrolithiasis	Kidney Stones Stone - Kidney/Ureter Kidney Calculi
Nephrolithiasis, Uric Acid	Nephrolithiasis, Uric Acid, Susceptibility To Uric Acid Urolithiasis Uric Acid Nephrolithiasis UAN Acute Urate Nephropathy Urolithiasis, Uric Acid Urolithiasis, Uric Acid, Susceptibility To Uric Acid Renal Calculus
Hyperuricemia	Blood Urate Raized Uricacidemia
Gout	Gouty Arthritis Articular Gout Gouty Arthropathy Arthritis, Gouty Arthritis Gouty Idiopathic Gout Idiopathic Gout, Unspecified Site Gouty Bursitis Uratic Arthritis Gout Nos Gouty Gouty Diathesis
Renal Artery Atheroma	Atherosclerosis Of Renal Artery Renal Atherosclerosis Atherosclerotic Renal Disease Ras - [Renal Artery Stenosis] Renal Arterial Arteriosclerosis Renal Arterial Arteriosclerotic Disease Renal Arterial Stricture Renal Artery Stricture Renal Artery Stenosis Of Unknown Cause Renal Artery Stenosis Due To Atherosclerosis Renal Artery Stenosis Renal Artery Arteriosclerotic Disease Renal Artery Arteriosclerosis
Tubulointerstitial Kidney Disease, Autosomal Dominant, 1	Familial Juvenile Hyperuricemic Nephropathy Mckd2 Familial Juvenile Hyperuricemic Nephropathy Type 1 Fjhn Medullary Cystic Kidney Disease 2 Uromodulin-Associated Kidney Disease Medullary Cystic Kidney Disease Type 2 ADTKD1 Hnfj1 Glomerulocystic Kidney Disease With Hyperuricemia And Isosthenuria Adtkd-Umod Familial Juvenile Hyperuricemic Nephropathy 1 Umod-Related Adtkd Umod-Related Autosomal Dominant Tubulointerstitial Kidney Disease Hyperuricemic Nephropathy, Familial Juvenile, 1 Gouty Nephropathy, Familial Juvenile Medullary Cystic Kidney Disease 2, Autosomal Dominant Admckd2 Autosomal Dominant Tubulointerstitial Kidney Disease Due To Umod Mutations Adtkd Due To Umod Mutations Autosomal Dominant Tubulointerstitial Kidney Disease, Umod-Related Autosomal Dominant Medullary Cystic Kidney Disease Type 2 Umod-Associated Kidney Disease Uromodulin Kidney Disease Familial Gout-Kidney Disease Familial Gouty Nephropathy Umak Umod-Related Kidney Disease Uromodulin Storage Disease Fjhn1 Gouty Nephropathy Familial Juvenile Nephropathy Familial With Gout Hyperuricemic Nephropathy, Familial Juvenile 1 Hyperuricemic Nephropathy, Familial Juvenile Kidney Disease, Glomerulocystic, With Hyperuricemia And Isosthenuria Nephropathy, Hyperuricemic, Juvenile, Familial, Type 1 Kidney Disease, Cystic, Medullary, Type 2 Medullary Cystic Kidney Disease Type Ii Familial Juvenile Gout
Xanthinuria	Xanthine Dehydrogenase Deficiency Xanthine Oxidase Deficiency Hereditary Xanthinuria Xanthic Urolithiasis Xanthine Stone Disease Xanthinuria, Type I Combined Deficiency Of Xanthine Dehydrogenase And Aldehyde Oxidase Xdh Deficiency Classic Xanthinuria Xanthinuria, Type Ii Classical Xanthinuria Xanthine Calculus
Hyperuricemia, Hprt-Related	Hprt-Related Gout Kelley-Seegmiller Syndrome Hprt Deficiency, Partial HRH Gout, Hprt-Related Hprt1 Deficiency, Partial Hrpt-Related Hyperuricemia Hprt Deficiency, Grade I Hprt Partial Deficiency Hprt-Related Hyperuricemia Hprt1 Partial Deficiency Hypoxanthine Guanine Phosphoribosyltransferase 1 Partial Deficiency Hypoxanthine Guanine Phosphoribosyltransferase Deficiency, Grade I Hypoxanthine Guanine Phosphoribosyltransferase Partial Deficiency Partial Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency Hypoxanthine Guanine Phosphoribosyltransferase 1 Deficiency, Partial Hyperuricemia, Hrpt-Related
Purine-Pyrimidine Metabolic Disorder	Inborn Errors Of Purine-Pyrimidine Metabolism Disorder Of Purine Or Pyrimidine Metabolism
Lesch-Nyhan Syndrome	Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency LNS Hprt Deficiency Complete Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency Hypoxanthine Guanine Phosphoribosyltransferase Deficiency X-Linked Hyperuricemia Choreoathetosis Self-Mutilation Syndrome Hprt1 Deficiency Hprt Deficiency, Complete Deficiency Of Imp Pyrophosphorylase Hgprt Deficiency Lesch-Nyhan Disease Hypoxanthine Guanine Phosphoribosyltransferase 1 Deficiency Hg-Prt Deficiency Hypoxanthine-Guanine-Phosphoribosyltransferase Deficiency Lesch - Nyhan Syndrome Hprt1 Disorders Lesch Nyhan Syndrome Complete Hprt Deficiency Complete Lesch Nyhan Disease Complete Hprt Deficiency Deficiency Of Guanine Phosphoribosyltransferase Deficiency Of Hypoxanthine Phosphoribosyltransferase Hypoxanthine Phosphoribosyltransferase Deficiency Juvenile Gout, Choreoathetosis, Mental Retardation Syndrome Juvenile Hyperuricemia Syndrome Lnd Primary Hyperuricemia Syndrome Total Hprt Deficiency Total Hypoxanthine-Guanine Phosphoribosyl Transferase Deficiency X-Linked Primary Hyperuricemia X-Linked Uric Aciduria Enzyme Defect Hprt Complete Deficiency Hprt Deficiency Grade Iv Hypoxanthine Guanine Phosphoribosyltransferase Complete Deficiency Hypoxanthine Guanine Phosphoribosyltransferase Deficiency, Grade Iv Hypoxanthine-Guanine Phosphoribosyltransferase 1 Deficiency Hprt - [ Hypoxanthine-Guanine Phosphoribosyltransferase] Complete Deficiency Total Hgprt - [Hypoxanthine-Guanine Phosphoribosyltransferase] Deficiency
Renal Artery Disease	Renal Vascular Disease Vascular Disorder Of Kidney Renal Vascular Disorder
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13177	SLC2A9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SLC2A9	VGNC	VGNC:34804
Rattus norvegicus	SLC2A9	RGD	RGD:1597012
Macaca mulatta	SLC2A9	VGNC	VGNC:77467
Canis familiaris	SLC2A9	VGNC	VGNC:46345
Mus musculus	SLC2A9	MGD	MGI:2152844
Felis catus	SLC2A9	VGNC	VGNC:65307
Others	SLC2A9	NCBI