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NT5M - 5',3'-nucleotidase, mitochondrial Gene

Also Known as mdN; dNT2; dNT-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 56953

About NT5M

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:17,303,373-17,347,663 (from NCBI)

This gene has 7 transcripts (splice variants), 186 orthologues and 1 paralogue. Broad expression in testis (RPKM 2.8), bone marrow (RPKM 2.2) and 23 other tissues.

Summary

This gene encodes a 5' nucleotidase that localizes to the mitochondrial matrix. This enzyme dephosphorylates the 5'- and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

NT5M Products (1)

mRNA	Protein	Name
NM_020201.4	NP_064586.1	5'(3')-deoxyribonucleotidase, mitochondrial precursor

NT5M Protein Structure

NT5C

0
100
200
228 a.a.

Protein Preferred Names	Protein Names
5'(3')-deoxyribonucleotidase, mitochondrial	5' nucleotidase, mitochondrial

Related Diseases

Diseases	Alias
Smith-Magenis Syndrome	SMS Chromosome 17p11.2 Deletion Syndrome 17p11.2 Microdeletion Syndrome 17p11.2 Monosomy Chromosome 17p Deletion Syndrome Del(17) P11.2 17p- Syndrome Deletion 17p Syndrome Partial Monosomy 17p
Mitochondrial Dna Depletion Syndrome 4b	Mitochondrial Neurogastrointestinal Encephalopathy Syndrome Mngie Syndrome Thymidine Phosphorylase Deficiency MTDPS4B Mitochondrial Neurogastrointestinal Encephalopathy Disease Mngie Myoneurogastrointestinal Encephalopathy Syndrome Ogimd Oculogastrointestinal Muscular Dystrophy Polip Polyneuropathy, Ophthalmoplegia, Leukoencephalopathy, And Intestinal Pseudo-Obstruction Mitochondrial Neurogastrointestinal Encephalopathy Syndrome, Polg-Related Mngie, Polg-Related Mepop Mitochondrial Myopathy With Sensorimotor Polyneuropathy, Ophthalmoplegia, And Pseudo-Obstruction Mngie Disease Mitochondrial Dna Depletion Syndrome 4b Mngie Type Mitochondrial Neurogastrointestinal Encephalopathy Syndrome Polg-Related Mngie Polg-Related Mitochondrial Dna Depletion Syndrome, Type 4b Visceral Myopathy Familial External Ophthalmoplegia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09615	NT5M Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21397	Nt5m Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27916	Nt5m Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NT5M	VGNC	VGNC:99312
Bos taurus	NT5M	VGNC	VGNC:32297
Mus musculus	NT5M	MGD	MGI:1917127
Rattus norvegicus	NT5M	RGD	RGD:1309622
Canis familiaris	NT5M	VGNC	VGNC:44001
Macaca mulatta	NT5M	VGNC	VGNC:99192
Others	NT5M	NCBI