NIT2 - nitrilase family member 2 Gene

Also Known as HEL-S-8a

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 56954

About NIT2

Cytogenetic location: 3q12.2 Genomic coordinates (GRCh38): 3:100,334,757-100,361,635 (from NCBI)

This gene has 7 transcripts (splice variants), 215 orthologues and 2 paralogues. Ubiquitous expression in kidney (RPKM 49.7), liver (RPKM 37.5) and 25 other tissues.

Summary

Enables omega-amidase activity. Involved in asparagine metabolic process; glutamine metabolic process; and oxaloacetate metabolic process. Located in centrosome and cytosol. [provided by Alliance of Genome Resources, Apr 2022]

NIT2 Products (1)

mRNA	Protein	Name
NM_020202.5	NP_064587.1	omega-amidase NIT2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables omega-amidase activity	IDA IDA: Inferred from direct assay	22674578	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in asparagine metabolic process	IDA IDA: Inferred from direct assay	22674578	GOA
involved in glutamine metabolic process	IDA IDA: Inferred from direct assay	22674578	GOA
involved in oxaloacetate metabolic process	IDA IDA: Inferred from direct assay	22674578	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NIT2 Protein Structure

CN_hydrolase

0
100
200
276 a.a.

Protein Preferred Names	Protein Names
omega-amidase NIT2	Nit protein 2

Related Diseases

Diseases	Alias
Histidinemia	Histidine Ammonia-Lyase Deficiency Hal Deficiency Histidase Deficiency His Deficiency Histidinuria Hyperhistidinemia HISTID Histidinuria Renal Tubular Defect
Atrial Septal Defect 4	ASD4 Atrial Heart Septal Defect 4 Septal Defect, Atrial, Type 4
Histidine Metabolism Disease	Disturbances Of Histidine Metabolism Disorder Of Histidine Metabolism Disturbance Of Histidine Metabolism
Alkaptonuria	Homogentisic Acid Oxidase Deficiency Alcaptonuria AKU Deficiency Of Homogentisicase Homogentisate 1,2-Dioxygenase Deficiency Alkaptonuric Ochronosis Homogentisic Acidura Ochronosis, Hereditary Hereditary Ochronosis Ochronosis Homogentisicaciduria Deficiency Of Homogentisate Oxygenase

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09311	NIT2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22257	Nit2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28779	Nit2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NIT2	MGD	MGI:1261838
Felis catus	NIT2	VGNC	VGNC:102789
Canis familiaris	NIT2	VGNC	VGNC:43823
Macaca mulatta	NIT2	VGNC	VGNC:75281
Bos taurus	NIT2	VGNC	VGNC:32090
Rattus norvegicus	NIT2	RGD	RGD:1310494
Others	NIT2	NCBI