REXO4 - RNA exonuclease 4 Gene

Also Known as REX4; XPMC2; XPMC2H

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57109

Summary

Enables DNA binding activity and Nuclease activity. Involved in DNA catabolic process and DNA repair. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jun 2026]
Ubiquitous expression in ovary (RPKM 10.2), testis (RPKM 9.8) and 25 other tissues.

REXO4 Products (4)

mRNA Protein Name
NM_001279349.2 NP_001266278.1 RNA exonuclease 4 isoform 2
NM_001279350.2 NP_001266279.1 RNA exonuclease 4 isoform 3
NM_001279351.1 NP_001266280.1 RNA exonuclease 4 isoform 4
NM_020385.4 NP_065118.2 RNA exonuclease 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 3'-5' exonuclease activity IDA
IDA: Inferred from direct assay
21602889 GOA
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
21602889 GOA
enables endonuclease activity IDA
IDA: Inferred from direct assay
21602889 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables single-stranded DNA binding IDA
IDA: Inferred from direct assay
21602889 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA catabolic process IDA
IDA: Inferred from direct assay
21602889 GOA
involved in DNA repair IDA
IDA: Inferred from direct assay
21602889 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

REXO4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
REXO4 Q9GZR2 DNM2 Homo sapiens P50570-2
Validated Y2H
32814053
Intra
REXO4 Q9GZR2 DNM2 Homo sapiens P50570-2
Y2H Pooling
32814053
Intra
REXO4 Q9GZR2 DNM2 Homo sapiens P50570-2
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11863 REXO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11864 REXO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20094 Rexo2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26597 Rexo2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown