RHBG - Rh family B glycoprotein Gene

Also Known as SLC42A2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57127

About RHBG

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:156,366,046-156,385,219 (from NCBI)

This gene has 9 transcripts (splice variants), 210 orthologues and 4 paralogues. Biased expression in kidney (RPKM 4.7), ovary (RPKM 3.9) and 5 other tissues.

Summary

This gene encodes one of two non-erythroid members of the Rhesus (Rh) protein family. Non-erythroid Rh protein family members are mainly expressed in the kidney and belong to the methylammonium-ammonium permease/ammonia transporters superfamily. All Rh family proteins are predicted to be transmembrane proteins with 12 membrane spanning domains and intracytoplasmic N- and C-termini. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

RHBG Products (6)

mRNA Protein Name
NM_001256395.2 NP_001243324.1 ammonium transporter Rh type B isoform b
NM_001256396.2 NP_001243325.1 ammonium transporter Rh type B isoform c
NM_001412175.1 NP_001399104.1 ammonium transporter Rh type B isoform d precursor
NM_001412176.1 NP_001399105.1 ammonium transporter Rh type B isoform e
NM_001412177.1 NP_001399106.1 ammonium transporter Rh type B isoform f
NM_020407.5 NP_065140.3 ammonium transporter Rh type B isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ammonium channel activity IDA
IDA: Inferred from direct assay
15929723 GOA
enables ankyrin binding IPI
IPI: Inferred from physical interaction
15611082 GOA
enables carbon dioxide transmembrane transporter activity IDA
IDA: Inferred from direct assay
24077989 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in ammonium transmembrane transport IDA
IDA: Inferred from direct assay
15929723 GOA
involved in transepithelial ammonium transport IDA
IDA: Inferred from direct assay
18032481 GOA
Cellular Component GO Annotation Evidence References Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
15611082 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
11024028 GOA
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
15611082 GOA
located in spectrin-associated cytoskeleton IMP
IMP: Inferred from mutant phenotype
18635543 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RHBG Protein Structure

Ammonium_transp

Ammonium_transp: Ammonium Transporter Family (26 - 417)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 441 a.a.
Protein Preferred Names Protein Names

ammonium transporter Rh type B

  • Rhesus blood group, B glycoprotein

Related Diseases

Diseases Alias
Hemolytic Disease Of Fetus And Newborn, Rh-Induced

  • Rh Deficiency Syndrome

  • Rh Disease

  • HDFNRH

  • Rh Fetomaternal Incompatibility

  • Rh-Null Syndrome
Pseudohypoaldosteronism, Type I, Autosomal Recessive

  • Autosomal Recessive Pseudohypoaldosteronism Type 1

  • PHA1B

  • Pseudohypoaldosteronism Type 1

  • Pseudohypoaldosteronism, Type I

  • Generalized Pha1

  • Generalized Pseudohypoaldosteronism Type 1

  • Pseudohypoaldosteronism Type 1 Autosomal Recessive

  • Pha1

  • Pseudohypoaldosteronism

  • Pha I, Autosomal Recessive

  • Autosomal Recessive Pha 1

  • Pseudohypoaldosteronism Type 1, Recessive

  • Pseudohypoaldosteronism Type I

  • Autosomal Recessive Pha1

  • Pha Type 1

  • Pseudohypoaldosteronism 1, Autosomal Recessive

  • Multisystem Pseudohypoaldosteronism

  • Pha Type I, Autosomal Recessive

  • Pseudohypoaldosteronism Type I, Autosomal Recessive
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11938 RHBG Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RHBG VGNC VGNC:55671
Rattus norvegicus RHBG RGD RGD:727813
Mus musculus RHBG MGD MGI:1927379
Felis catus RHBG VGNC VGNC:99809
Macaca mulatta RHBG VGNC VGNC:99814
Others RHBG NCBI