CYP20A1 - cytochrome P450 family 20 subfamily A member 1 Gene

Also Known as CYP-M

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57404

About CYP20A1

This gene has 9 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in thyroid (RPKM 2.4), kidney (RPKM 1.7) and 25 other tissues.

Summary

This gene encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. This protein lacks one amino acid of the conserved heme binding site. It also lacks the conserved I-helix motif AGX(D,E)T, suggesting that its substrate may carry its own oxygen. [provided by RefSeq, Jul 2008]

CYP20A1 Products (13)

mRNA Protein Name
NM_001371695.1 NP_001358624.1 cytochrome P450 20A1 isoform 1
NM_001371696.1 NP_001358625.1 cytochrome P450 20A1 isoform 3
NM_001371697.1 NP_001358626.1 cytochrome P450 20A1 isoform 3
NM_001371698.1 NP_001358627.1 cytochrome P450 20A1 isoform 3
NM_001371699.1 NP_001358628.1 cytochrome P450 20A1 isoform 6
NM_001371700.1 NP_001358629.1 cytochrome P450 20A1 isoform 4
NM_001371701.1 NP_001358630.1 cytochrome P450 20A1 isoform 4
NM_001371702.1 NP_001358631.1 cytochrome P450 20A1 isoform 5
NM_001371703.1 NP_001358632.1 cytochrome P450 20A1 isoform 5
NM_001371704.1 NP_001358633.1 cytochrome P450 20A1 isoform 5
NM_001371705.1 NP_001358634.1 cytochrome P450 20A1 isoform 5
NM_001371706.1 NP_001358635.1 cytochrome P450 20A1 isoform 5
NM_177538.3 NP_803882.1 cytochrome P450 20A1 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYP20A1 Protein Structure

p450

p450: Cytochrome P450 (43 - 446)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 462 a.a.
Protein Preferred Names Protein Names

cytochrome P450 20A1

  • cytochrome P450 monooxygenase

CYP20A1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CYP20A1 Q6UW02 PIEZO1 Homo sapiens Q92508
Anti Tag CoIP
33961781
Intra
CYP20A1 Q6UW02 PIEZO1 Homo sapiens Q92508
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Scabies

  • Sarcoptic Itch

  • Infestation By Sarcoptes Scabiei

  • Infestation By Sarcoptes Scabiei Var Hominis

  • Infestation By Sarcoptes Scabiei Var. Hominis
Keratomalacia

  • Vitamin A Deficiency

  • Night Blindness

  • Retinol Deficiency

  • Xerotic Keratitis

  • VAD

  • Vitamin A

  • Hypovitaminosis A

  • Bitot Spots

  • Bitot Spots In The Young Child

  • Conjunctival Xerosis With Bitot'S Spots

  • Vitamin A Deficiency With Cornea Xerosis

  • Vitamin A Deficiency With Cornea Ulceration Or Xerosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03444 CYP20A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CYP20A1 MGD MGI:1925201
Bos taurus CYP20A1 VGNC VGNC:110235
Rattus norvegicus CYP20A1 RGD RGD:735221
Macaca mulatta CYP20A1 VGNC VGNC:103631
Canis familiaris CYP20A1 VGNC VGNC:50351
Felis catus CYP20A1 VGNC VGNC:103335
Others CYP20A1 NCBI