PTMA - prothymosin alpha Gene

Also Known as TMSA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5757

About PTMA

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:231,708,525-231,713,551 (from NCBI)

This gene has 12 transcripts (splice variants) and 103 orthologues. Ubiquitous expression in bone marrow (RPKM 272.9), lymph node (RPKM 218.9) and 25 other tissues.

Summary

Enables DNA-binding transcription factor binding activity. Involved in negative regulation of apoptotic process. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PTMA Products (2)

mRNA Protein Name
NM_001099285.2 NP_001092755.1 prothymosin alpha isoform 1
NM_002823.5 NP_002814.3 prothymosin alpha isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
11897665 GOA
enables histone binding IPI
IPI: Inferred from physical interaction
29466338 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15607035 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16478804 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
8485135 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTMA Protein Structure

Prothymosin

Prothymosin: Prothymosin/parathymosin family (2 - 111)

  • 0
  • 100
  • 111 a.a.
Protein Preferred Names Protein Names

prothymosin alpha

  • gene sequence 28

PTMA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PTMA P06454 NUPR1 Homo sapiens O60356
NMR
16478804
Intra
PTMA P06454 NUPR1 Homo sapiens O60356
Anti Bait CoIP
16478804
Intra
PTMA P06454 NUPR1 Homo sapiens O60356
Y2H
16478804
Intra
PTMA P06454 NUPR1 Homo sapiens O60356
Fluorescence Spectr
16478804
Intra
PTMA P06454 NUPR1 Homo sapiens O60356
CD
16478804
Intra
PTMA P06454 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
Intra
PTMA P06454 TERF2IP Homo sapiens Q9NYB0
BiFC
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PTMA Proteins

Cat. No. Product Name Accession Purity
HY-P75992 PTMA Protein, Human (GST) P06454-1 (S2-D111) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Hepatitis B

  • Chronic Hepatitis B

  • Hepatitis B Infection

  • Serum Hepatitis

  • HBV

  • Hepatitis B Chronic

  • Hbv, Susceptibility To

  • Hepatitis B, Chronic

  • Chronic Hepatitis B Without Delta Agent

  • Chronic Hbv - [Hepatitis B Virus] Infection

  • Hepatitis B Nos

  • Chronic Type B Viral Hepatitis

  • Hep B Nos
Invasive Malignant Thymoma

  • Infiltrating Thymoma

  • Thymoma Malignant Invasive

  • Invasive Thymoma And Thymic Carcinoma
Thymoma

  • Primary Thymic Epithelial Neoplasm

  • Primary Thymic Epithelial Tumor

  • Thymus Neoplasms
Viral Hepatitis

  • Animal Viral Hepatitis

  • Hepatitis, Viral, Animal

  • Human Viral Hepatitis

  • Viral Hepatitis With Hepatic Coma
Hepatoblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11405 PTMA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18967 Ptma Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25457 Ptma Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PTMA RGD RGD:61829
Felis catus PTMA VGNC VGNC:107609
Mus musculus PTMA MGD MGI:97803
Others PTMA NCBI