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NUPR1 - nuclear protein 1, transcriptional regulator Gene

Also Known as P8; COM1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26471

About NUPR1

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:28,532,708-28,538,974 (from NCBI)

This gene has 3 transcripts (splice variants), 159 orthologues and 1 paralogue. Broad expression in thyroid (RPKM 197.1), pancreas (RPKM 192.3) and 21 other tissues.

Summary

Enables DNA binding activity and transcription coactivator activity. Involved in several processes, including regulation of cellular catabolic process; regulation of generation of precursor metabolites and energy; and regulation of programmed cell death. Acts upstream of or within negative regulation of cell cycle. Located in intercellular bridge; nucleoplasm; and perinuclear region of cytoplasm. Part of protein-DNA complex. [provided by Alliance of Genome Resources, Apr 2022]

NUPR1 Products (2)

mRNA	Protein	Name
NM_001042483.2	NP_001035948.1	nuclear protein 1 isoform a
NM_012385.3	NP_036517.1	nuclear protein 1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	EXP EXP: Inferred from Experiment	11056169	GOA
enables DNA binding	IDA IDA: Inferred from direct assay	11056169	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11940591	GOA
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	11940591	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	20181828	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16478804	GOA
involved in negative regulation of autophagosome assembly	IMP IMP: Inferred from mutant phenotype	20181828	GOA
involved in negative regulation of autophagy	IMP IMP: Inferred from mutant phenotype	20181828	GOA
involved in negative regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	20181828	GOA
acts upstream of or within negative regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	19723804	GOA
involved in negative regulation of glycolytic process	IMP IMP: Inferred from mutant phenotype	30451898	GOA
involved in negative regulation of programmed necrotic cell death	IMP IMP: Inferred from mutant phenotype	30451898	GOA
involved in positive regulation of cell cycle	IDA IDA: Inferred from direct assay	10092851	GOA
involved in positive regulation of intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	27031958	GOA
involved in positive regulation of oxidative phosphorylation	IMP IMP: Inferred from mutant phenotype	30451898	GOA
involved in positive regulation of proteasomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	16300740	GOA
involved in regulation of response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	30451898	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16300740	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10092851	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16300740	GOA
part of protein-DNA complex	IDA IDA: Inferred from direct assay	11056169	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUPR1 Protein Structure

Phospho_p8

0
82 a.a.

Protein Preferred Names	Protein Names
nuclear protein 1	candidate of metastasis 1

NUPR1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NUPR1	O60356	CAPN2	Homo sapiens	P17655	Validated Y2H	32814053
Intra	NUPR1	O60356	CAPN2	Homo sapiens	P17655	Y2H Array	32814053
Intra	NUPR1	O60356	CAPN2	Homo sapiens	P17655	Y2H Pooling	32814053
Intra	NUPR1	O60356	CFAP100	Homo sapiens	Q494V2-2	Y2H Pooling	32814053
Intra	NUPR1	O60356	CFAP100	Homo sapiens	Q494V2-2	Validated Y2H	32814053
Intra	NUPR1	O60356	CFAP100	Homo sapiens	Q494V2-2	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-B0532A	Trifluoperazine dihydrochloride	99.98%	Unkown
HY-B0532	Trifluoperazine	99.87%	Unkown
HY-B0532B	Trifluoperazine dimaleate	/	Unkown

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111838A	ZZW-115 hydrochloride	Inducer	98.09%	Unkown
HY-111838	ZZW-115	Activator	99.88%	Unkown
HY-RS09702	NUPR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-B0532AS	Trifluoperazine-d3 dihydrochloride		/	Unkown
HY-RS17469	Nupr1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23927	Nupr1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NUPR1	VGNC	VGNC:32369
Macaca mulatta	NUPR1	VGNC	VGNC:75493
Felis catus	NUPR1	VGNC	VGNC:63929
Rattus norvegicus	NUPR1	RGD	RGD:69363
Canis familiaris	NUPR1	VGNC	VGNC:54052
Mus musculus	NUPR1	MGD	MGI:1891834
Others	NUPR1	NCBI