DENND1A - DENN domain containing 1A Gene

Homo sapiens

Also known as FAM31A; KIAA1608

Gene ID: 57706 | Gene type: protein coding

About DENND1A

Cytogenetic location: 9q33.3 Genomic coordinates (GRCh38): 9:123,379,658-123,930,126 (from NCBI)

This gene has 13 transcripts (splice variants), 216 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 4.6), kidney (RPKM 4.6) and 25 other tissues.

Summary

Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]

DENND1A Products(10)

mRNA	Protein	Name
NM_001352964.2	NP_001339893.1	DENN domain-containing protein 1A isoform 3
NM_001352965.2	NP_001339894.1	DENN domain-containing protein 1A isoform 4
NM_001352966.2	NP_001339895.1	DENN domain-containing protein 1A isoform 5
NM_001352967.2	NP_001339896.1	DENN domain-containing protein 1A isoform 6
NM_001352968.2	NP_001339897.1	DENN domain-containing protein 1A isoform 7
NM_001393654.1	NP_001380583.1	DENN domain-containing protein 1A isoform 8
NM_001400446.1	NP_001387375.1	DENN domain-containing protein 1A isoform 9
NM_001400449.1	NP_001387378.1	DENN domain-containing protein 1A isoform 10
NM_020946.2	NP_065997.1	DENN domain-containing protein 1A isoform 1
NM_024820.3	NP_079096.2	DENN domain-containing protein 1A isoform 2

DENND1A Protein Structure

uDENN

DENN

dDENN

0
200
400
600
800
1009 a.a.

Protein Preferred Names

Protein Names

DENN domain-containing protein 1A

DENN/MADD domain containing 1A

Recombinant DENND1A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71599	DENND1A Protein, Human (His-SUMO)	Q8TEH3-2 (M1-H559)	≥95%

Related Diseases

Diseases

Alias

Polycystic Ovary Syndrome

Polycystic Ovarian Syndrome	Pcos
Polycystic Ovarian Disease	Polycystic Ovaries
Stein-Leventhal Syndrome	Multicystic Ovaries
Polycystic Ovary	Sclerocystic Ovaries
Sclerocystic Ovary Syndrome	Stein-Leventhal Synd.
Cystic Disease Of Ovaries	Cystic Disease Of Ovary
Pco	Pcod
Sclerocystic Ovarian Degeneration	Polycystic Ovary Syndrome, Susceptibility To
Pcos - [Polycystic Ovary Syndrome]	Polycystic Ovary Nos
Pco - [Polycystic Ovary]

Ovarian Disease

Ovarian Dysfunction	Ovarian Diseases
Ovarian Disorders	Disorder Of Endocrine Ovary

Disorder Of Sexual Development

Disorder Of Sex Development	Disorders Of Sex Development
Sex Development Disorder	Sex Differentiation Disease
Dsd	Sex Differentiation Disorders

Lipoid Congenital Adrenal Hyperplasia

Congenital Adrenal Hyperplasia	Congenital Lipoid Adrenal Hyperplasia Due To Star Deficency
Congenital Lipoid Adrenal Hyperplasia	Lipoid Cah
Lipoid Adrenal Hyperplasia	Adrenal Hyperplasia 1
Cah	Clah
LCAH	Adrenal Hyperplasia I
Lipoid Hyperplasia, Congenital, Of Adrenal Cortex With Male Pseudohermaphroditism	Congenital Adrenal Hyperplasia Lipoid
Adrenal Hyperplasia, Congenital	Congenital Adrenal Hyperplasia, Lipoid
AH1	Congenital Lipoid Hyperplasia Of Adrenal Cortex With Male Pseudohermaphroditism
Adrenal Hyperplasia Congenital	Hyperplasia, Adrenal, Lipoid, Congenital
Congenital Adrenogenital Disorders Associated With Enzyme Deficiency	Congenital Adrenal Cortical Hyperplasia
Congenital Adrenal Gland Hyperplasia	Congenital Adrenogenital Syndrome
Congenital Hyperadrenocorticism	Congenital Adrenogenitalism
Congenital Female Adrenal Pseudohermaphroditism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03685	DENND1A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DENND1A	VGNC	VGNC:102917
Mus musculus	DENND1A	MGD	MGI:2442794
Canis familiaris	DENND1A	VGNC	VGNC:39884
Bos taurus	DENND1A	VGNC	VGNC:27993
Rattus norvegicus	DENND1A	RGD	RGD:1307927
Macaca mulatta	DENND1A	VGNC	VGNC:71814
Others	DENND1A	NCBI

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