SQOR - sulfide quinone oxidoreductase Gene

Homo sapiens

Also known as SQR; SQRDL; CGI-44; PRO1975

Gene ID: 58472 | Gene type: protein coding

About SQOR

Cytogenetic location: 15q21.1 Genomic coordinates (GRCh38): 15:45,631,148-45,691,281 (from NCBI)

This gene has 8 transcripts (splice variants), 222 orthologues and is associated with 1 phenotype. Broad expression in colon (RPKM 63.6), esophagus (RPKM 32.6) and 21 other tissues.

Summary

The protein encoded by this gene may function in mitochondria to catalyze the conversion of sulfide to persulfides, thereby decreasing toxic concencrations of sulfide. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2012]

SQOR Products(2)

mRNA	Protein	Name
NM_001271213.2	NP_001258142.1	sulfide:quinone oxidoreductase, mitochondrial
NM_021199.4	NP_067022.1	sulfide:quinone oxidoreductase, mitochondrial

SQOR Protein Structure

Pyr_redox_2

0
100
200
300
400
450 a.a.

Protein Preferred Names

Protein Names

sulfide:quinone oxidoreductase, mitochondrial

sulfide dehydrogenase like

Related Diseases

Diseases

Alias

Sulfide:Quinone Oxidoreductase Deficiency

SQORD

Sulfide Quinone Oxidoreductase Deficiency

Encephalopathy, Ethylmalonic

Ethylmalonic Encephalopathy	EE
Epema Syndrome	Encephalopathy, Petechiae, And Ethylmalonic Aciduria
Ethe1 Deficiency	Eme
Syndrome Of Encephalopathy, Petechiae, And Ethylmalonic Aciduria

Cystathioninuria

Cystathionase Deficiency	Gamma-Cystathionase Deficiency
Cystathione Gamma-Lyase Deficiency Syndrome	Cystathionine Gamma-Lyase Deficiency Syndrome
CSTNU

Leigh Syndrome

Leigh Disease	Infantile Subacute Necrotizing Encephalopathy
Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency	LS
Sne	Leigh'S Disease
Leigh Syndrome Due To Mitochondrial Complex I Deficiency	Necrotizing Encephalopathy, Infantile Subacute, Of Leigh
Subacute Necrotizing Encephalomyelopathy	Necrotizing Encephalopathy Infantile Subacute Of Leigh
Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency	Infantile Necrotizing Encephalomyelopathy
Juvenile Subacute Necrotizing Encephalomyelopathy	Leigh'S Necrotizing Encephalopathy
Subacute Necrotizing Encephalopathy	Juvenile Subacute Necrotizing Encephalopathy
Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency	Leigh Syndrome Due To Mitochondrial Complex V Deficiency
Encephalopathy, Subacute Necrotizing, Infantile	Encephalopathy, Subacute Necrotizing, Juvenile
Maternally Inherited Leigh Syndrome	Subacute Necrotising Encephalomyelopathy
Subacute Necrotising Encephalopathy

Lactic Acidosis

Acidosis, Lactic

Acidosis Lactic

Interstitial Nephritis, Karyomegalic

Karyomegalic Interstitial Nephritis	KMIN
Kin	Systemic Karyomegaly
Karyomegalic Tubulointerstitial Nephritis	Ktn

Leber Congenital Amaurosis 1

LCA1	Amaurosis Congenita Of Leber I
Lca	Retinal Blindness, Congenital
Crb	Leber Congenital Amaurosis Type I
Leber Congenital Amaurosis, Type 1	Amaurosis Congenita Of Leber, Type 1

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-141552	FC9402	99.61%	Unkown
HY-144439	HTS07545	99.67%	Unkown
HY-RS13744	SQOR Human Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SQOR	RGD	RGD:1564504
Bos taurus	SQOR	VGNC	VGNC:101453
Macaca mulatta	SQOR	VGNC	VGNC:99244
Mus musculus	SQOR	MGD	MGI:1929899
Felis catus	SQOR	VGNC	VGNC:101465
Canis familiaris	SQOR	VGNC	VGNC:101445

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