ARHGAP22 - Rho GTPase activating protein 22 Gene

Homo sapiens

Also known as RhoGAP2; RhoGap22

Gene ID: 58504 | Gene type: protein coding

About ARHGAP22

Cytogenetic location: 10q11.22-q11.23 Genomic coordinates (GRCh38): 10:48,429,831-48,656,265 (from NCBI)

This gene has 15 transcripts (splice variants), 122 orthologues and 2 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the Ras superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

ARHGAP22 Products(8)

mRNA	Protein	Name
NM_001256024.2	NP_001242953.1	rho GTPase-activating protein 22 isoform 1
NM_001256025.3	NP_001242954.1	rho GTPase-activating protein 22 isoform 2
NM_001256026.2	NP_001242955.1	rho GTPase-activating protein 22 isoform 4
NM_001347735.2	NP_001334664.1	rho GTPase-activating protein 22 isoform 7
NM_001347736.2	NP_001334665.1	rho GTPase-activating protein 22 isoform 8
NM_001347737.2	NP_001334666.1	rho GTPase-activating protein 22 isoform 9
NM_001347738.2	NP_001334667.1	rho GTPase-activating protein 22 isoform 2
NM_021226.4	NP_067049.2	rho GTPase-activating protein 22 isoform 3

ARHGAP22 Protein Structure

RhoGAP

0
200
400
600
698 a.a.

Protein Preferred Names

Protein Names

rho GTPase-activating protein 22

rho-type GTPase-activating protein 22

Related Diseases

Diseases

Alias

Conduct Disorder

Myasthenic Syndrome, Congenital, 6, Presynaptic

Familial Infantile Myasthenia	CMS6
Cmsea	Congenital Myasthenic Syndrome 6
Familial Infantile Myasthenia Gravis 2	Fimg2
Myasthenic Syndrome, Congenital, Associated With Episodic Apnea	Myasthenic Syndrome, Presynaptic, Congenital, Associated With Episodic Apnea
Congenital Myasthenic Syndrome Type Ia2, Formerly	Cms1a2, Formerly
Cms Ia2, Formerly	Myasthenia, Familial Infantile, Formerly
Fim, Formerly	Myasthenia Gravis, Familial Infantile, 2, Formerly
Fimg2, Formerly	Cms Ia2
Cms1a2	Congenital Myasthenic Syndrome 6, Presynaptic
Congenital Myasthenic Syndrome Type Ia2	Congenital Presynaptic Myasthenic Syndrome Associated With Episodic Apnea
Fim	Cms1a
Cms-Ea	Cms Ia
Congenital Myasthenic Syndrome Pre-Synaptic Associated With Episodic Apnea	Congenital Myasthenic Syndrome Type 1a
Congenital Myasthenic Syndrome Type Ia	Myasthenic Syndrome, Congenital, Type 6, Presynaptic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00922	ARHGAP22 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ARHGAP22	RGD	RGD:1307237
Canis familiaris	ARHGAP22	VGNC	VGNC:52984
Mus musculus	ARHGAP22	MGD	MGI:2443418
Bos taurus	ARHGAP22	VGNC	VGNC:26081
Macaca mulatta	ARHGAP22	VGNC	VGNC:69931

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