ARHGAP22 - Rho GTPase activating protein 22 Gene

Also Known as RhoGAP2; RhoGap22

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 58504

About ARHGAP22

Cytogenetic location: 10q11.22-q11.23 Genomic coordinates (GRCh38): 10:48,429,831-48,656,265 (from NCBI)

This gene has 15 transcripts (splice variants), 122 orthologues and 2 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the Ras superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

ARHGAP22 Products (8)

mRNA Protein Name
NM_001256024.2 NP_001242953.1 rho GTPase-activating protein 22 isoform 1
NM_001256025.3 NP_001242954.1 rho GTPase-activating protein 22 isoform 2
NM_001256026.2 NP_001242955.1 rho GTPase-activating protein 22 isoform 4
NM_001347735.2 NP_001334664.1 rho GTPase-activating protein 22 isoform 7
NM_001347736.2 NP_001334665.1 rho GTPase-activating protein 22 isoform 8
NM_001347737.2 NP_001334666.1 rho GTPase-activating protein 22 isoform 9
NM_001347738.2 NP_001334667.1 rho GTPase-activating protein 22 isoform 2
NM_021226.4 NP_067049.2 rho GTPase-activating protein 22 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
21078624 GOA
Biological Process GO Annotation Evidence Références Source
involved in regulation of postsynapse organization IDA
IDA: Inferred from direct assay
21926414 GOA
involved in regulation of postsynapse organization IMP
IMP: Inferred from mutant phenotype
21926414 GOA
Cellular Component GO Annotation Evidence Références Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
21926414 GOA
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
21926414 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP22 Protein Structure

PH

PH: PH domain (39 - 143)

RhoGAP

RhoGAP: RhoGAP domain (173 - 321)

  • 0
  • 200
  • 400
  • 600
  • 698 a.a.
Protein Preferred Names Protein Names

rho GTPase-activating protein 22

  • rho-type GTPase-activating protein 22

ARHGAP22 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
ARHGAP22 Q7Z5H3 CCNDBP1 Homo sapiens O95273
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Conduct Disorder
Myasthenic Syndrome, Congenital, 6, Presynaptic

  • Familial Infantile Myasthenia

  • CMS6

  • Cmsea

  • Congenital Myasthenic Syndrome 6

  • Familial Infantile Myasthenia Gravis 2

  • Fimg2

  • Myasthenic Syndrome, Congenital, Associated With Episodic Apnea

  • Myasthenic Syndrome, Presynaptic, Congenital, Associated With Episodic Apnea

  • Congenital Myasthenic Syndrome Type Ia2, Formerly

  • Cms1a2, Formerly

  • Cms Ia2, Formerly

  • Myasthenia, Familial Infantile, Formerly

  • Fim, Formerly

  • Myasthenia Gravis, Familial Infantile, 2, Formerly

  • Fimg2, Formerly

  • Cms Ia2

  • Cms1a2

  • Congenital Myasthenic Syndrome 6, Presynaptic

  • Congenital Myasthenic Syndrome Type Ia2

  • Congenital Presynaptic Myasthenic Syndrome Associated With Episodic Apnea

  • Fim

  • Cms1a

  • Cms-Ea

  • Cms Ia

  • Congenital Myasthenic Syndrome Pre-Synaptic Associated With Episodic Apnea

  • Congenital Myasthenic Syndrome Type 1a

  • Congenital Myasthenic Syndrome Type Ia

  • Myasthenic Syndrome, Congenital, Type 6, Presynaptic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS00922 ARHGAP22 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20663 Arhgap22 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27174 Arhgap22 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ARHGAP22 RGD RGD:1307237
Canis familiaris ARHGAP22 VGNC VGNC:52984
Mus musculus ARHGAP22 MGD MGI:2443418
Bos taurus ARHGAP22 VGNC VGNC:26081
Macaca mulatta ARHGAP22 VGNC VGNC:69931
Others ARHGAP22 NCBI