RPN2 - ribophorin II Gene

Homo sapiens

Also known as SWP1; RPNII; RIBIIR; RPN-II

Gene ID: 6185 | Gene type: protein coding

About RPN2

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:37,179,330-37,241,619 (from NCBI)

This gene has 9 transcripts (splice variants) and 208 orthologues. Ubiquitous expression in thyroid (RPKM 122.3), placenta (RPKM 121.1) and 25 other tissues.

Summary

This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

RPN2 Products(9)

mRNA	Protein	Name
NM_001135771.3	NP_001129243.1	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 2 precursor
NM_001324299.2	NP_001311228.1	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 3 precursor
NM_001324301.2	NP_001311230.1	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 4 precursor
NM_001324302.2	NP_001311231.1	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 5 precursor
NM_001324303.2	NP_001311232.1	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 6 precursor
NM_001324304.2	NP_001311233.1	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 7 precursor
NM_001324305.2	NP_001311234.1	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 8 precursor
NM_001324306.2	NP_001311235.1	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 9
NM_002951.5	NP_002942.2	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 1 precursor

RPN2 Protein Structure

Ribophorin_II

0
100
200
300
400
500
631 a.a.

Protein Preferred Names

Protein Names

dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit

Recombinant RPN2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76574	RPN2/Ribophorin II Protein, Human (HEK293, Fc)	P04844 (M1-V540)	≥95%
HY-P76575	RPN2/Ribophorin II Protein, Human (HEK293, His)	P04844/NP_002942.2 (L23-V540)	≥95%

Related Diseases

Diseases

Alias

Encephalitozoonosis

Infection By Encephalitozoon

Microsporidiosis

Infection By Microspora	Microsporidiasis
Infection By Microsporea	Infection By Microsporida
Intestinal Microsporidiosis	Microsporidia Infection
Infection By Microsporidia

Facial Clefting, Oblique, 1

Oculomaxillofacial Dysostosis	Oculomaxillofacial Dysplasia With Oblique Facial Clefts
OBLFC1	Oblique Facial Clefting 1
Tessier Number 4 Facial Cleft	Oblique Facial Cleft
Orbitofacial Cleft	Oblique Facial Clefts
Richieri Costa Gorlin Syndrome	Richieri-Costa-Gorlin Syndrome
Facial Clefting, Oblique, Type 1

Teebi Hypertelorism Syndrome 1

Teebi Hypertelorism Syndrome	Brachycephalofrontonasal Dysplasia
Hypertelorism, Teebi Type	TBHS1
Tbhs	Chromosome 22q11.2 Deletion Syndrome, Opitz Phenotype
Opitz Gbbb Syndrome Type Ii	Specc1l-Related Hypertelorism Syndrome
Opitz Gbbb Syndrome, Type Ii, Formerly	Gbbb2, Formerly
Opitz Bbbg Syndrome, Type Ii, Formerly	Bbbg2, Formerly
Opitz-G Syndrome, Type Ii, Formerly	Ogs2, Formerly
Opitz Bbb Syndrome, Type Ii, Formerly	Hypertelorism-Hypospadias Syndrome, Formerly
Hypertelorism With Esophageal Abnormality And Hypospadias, Formerly	Opitz Oculogenitolaryngeal Syndrome, Type Ii, Formerly
Opitz-Frias Syndrome, Formerly	Teebi Hypertelorism Syndrome-1
Craniofrontonasal Dysplasia, Teebi Type	Bbb Syndrome
Gbbb Syndrome	G Syndrome
Hypertelorism-Hypospadias Syndrome	Hypertelorism With Esophageal Abnormality And Hypospadias
Hypospadias-Dysphagia Syndrome	Ogs2
Opitz Bbbg Syndrome	Opitz-Frias Syndrome
Opitz Gbbb Syndrome, Autosomal Dominant	Opitz-G Syndrome, Type Ii
Opitz Oculogenitolaryngeal Syndrome, Type Ii	Opitz Gbbb Syndrome, Type Ii
Teebi Syndrome	Opitz-G Syndrome, Type 2
Opitz Gbbb Syndrome, X-Linked	Digeorge Syndrome

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive	Autosomal Recessive Mental Retardation
Autosomal Recessive Non-Syndromic Mental Retardation	Autosomal Recessive Non-Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12211	RPN2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RPN2	MGD	MGI:98085
Felis catus	RPN2	VGNC	VGNC:64742
Canis familiaris	RPN2	VGNC	VGNC:45722
Bos taurus	RPN2	VGNC	VGNC:34120
Rattus norvegicus	RPN2	RGD	RGD:62075
Macaca mulatta	RPN2	VGNC	VGNC:76925
Others	RPN2	NCBI