Irx6 - Iroquois homeobox 6 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 64379

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and DNA-binding transcription repressor activity, RNA polymerase II-specific. Acts upstream of or within detection of visible light; regulation of transcription, DNA-templated; and retina morphogenesis in camera-type eye. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; endocardial lining; genitourinary system; limb; and retina. Orthologous to human IRX6 (iroquois homeobox 6). [provided by Alliance of Genome Resources, Apr 2022]

Irx6 Products (2)

mRNA Protein Name
NM_001301137.1 NP_001288066.1 iroquois-class homeodomain protein IRX-6 isoform 2
NM_022428.3 NP_071873.2 iroquois-class homeodomain protein IRX-6 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
23172916 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
23172916 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within detection of visible light IMP
IMP: Inferred from mutant phenotype
23172916 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
23172916 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
23172916 MGI
acts upstream of or within retina layer formation IMP
IMP: Inferred from mutant phenotype
23172916 MGI
acts upstream of or within retinal bipolar neuron differentiation IMP
IMP: Inferred from mutant phenotype
23172916 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

iroquois-class homeodomain protein IRX-6

  • Iroquois related homeobox 6

  • homeodomain protein IRXB3

  • iroquois homeobox protein 6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06925 IRX6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Irx6 NCBI NCBI:79190