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DRGX - dorsal root ganglia homeobox Gene

Also Known as DRG11; PRRXL1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 644168

About DRGX

Cytogenetic location: 10q11.23 Genomic coordinates (GRCh38): 10:49,364,066-49,396,089 (from NCBI)

This gene has 1 transcript (splice variant), 204 orthologues and 50 paralogues. Biased expression in adrenal (RPKM 3.2) and skin (RPKM 0.2).

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including detection of temperature stimulus; nervous system development; and sensory perception of mechanical stimulus. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]

DRGX Products (1)

mRNA	Protein	Name
NM_001276451.2	NP_001263380.1	dorsal root ganglia homeobox protein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DRGX Protein Structure

Homeobox

OAR

0
100
200
263 a.a.

Protein Preferred Names	Protein Names
dorsal root ganglia homeobox protein	paired related homeobox-like 1

Related Diseases

Diseases	Alias
Chromosome 16p12.2-P11.2 Deletion Syndrome, 7.1- To 8.7-Mb	Chromosome 16p12.2-P11.2 Deletion Syndrome 16p11.2p12.2 Microdeletion Syndrome 16p11.2-P12.2 Microdeletion Syndrome Del(16)(P11.2p12.2) Monosomy 16p11.2p12.2 Chromosome Deletion Syndrome 16p12.2-P11.2
Myasthenic Syndrome, Congenital, 6, Presynaptic	Familial Infantile Myasthenia CMS6 Cmsea Congenital Myasthenic Syndrome 6 Familial Infantile Myasthenia Gravis 2 Fimg2 Myasthenic Syndrome, Congenital, Associated With Episodic Apnea Myasthenic Syndrome, Presynaptic, Congenital, Associated With Episodic Apnea Congenital Myasthenic Syndrome Type Ia2, Formerly Cms1a2, Formerly Cms Ia2, Formerly Myasthenia, Familial Infantile, Formerly Fim, Formerly Myasthenia Gravis, Familial Infantile, 2, Formerly Fimg2, Formerly Cms Ia2 Cms1a2 Congenital Myasthenic Syndrome 6, Presynaptic Congenital Myasthenic Syndrome Type Ia2 Congenital Presynaptic Myasthenic Syndrome Associated With Episodic Apnea Fim Cms1a Cms-Ea Cms Ia Congenital Myasthenic Syndrome Pre-Synaptic Associated With Episodic Apnea Congenital Myasthenic Syndrome Type 1a Congenital Myasthenic Syndrome Type Ia Myasthenic Syndrome, Congenital, Type 6, Presynaptic
Developmental And Epileptic Encephalopathy 28	DEE28 Epileptic Encephalopathy, Early Infantile, 28 Eiee28 Developmental And Epileptic Encephalopathy, 28 Early Infantile Epileptic Encephalopathy 28 Encephalopathy, Epileptic, Early Infantile, Type 28
Spinocerebellar Ataxia, Autosomal Recessive 12	Autosomal Recessive Spinocerebellar Ataxia 12 SCAR12 Spinocerebellar Ataxia With Mental Retardation And Epilepsy Autosomal Recessive Cerebellar Ataxia-Epilepsy-Intellectual Disability Syndrome Due To Wwox Deficiency Autosomal Recessive Spinocerebellar Ataxia Type 12 Spinocerebellar Ataxia, Autosomal Recessive, 12 Ataxia, Spinocerebellar, Autosomal Recessive, Type 12

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04011	DRGX Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DRGX	RGD	RGD:628616
Bos taurus	DRGX	VGNC	VGNC:28210
Macaca mulatta	DRGX	VGNC	VGNC:106037
Canis familiaris	DRGX	VGNC	VGNC:40099
Mus musculus	DRGX	MGD	MGI:2148204
Others	DRGX	NCBI