Syt4 - synaptotagmin 4 Gene

Rattus norvegicus

Gene ID: 64440 | Gene type: protein coding

About Syt4

Summary

Enables several functions, including phosphatidylserine binding activity; protein dimerization activity; and syntaxin binding activity. Involved in several processes, including dense core granule cytoskeletal transport; negative regulation of transport; and vesicle organization. Located in several cellular components, including astrocyte projection; neuronal cell body; and secretory vesicle. Is intrinsic component of neuronal dense core vesicle membrane. Biomarker of visual epilepsy. Orthologous to human SYT4 (synaptotagmin 4). [provided by Alliance of Genome Resources, Apr 2022]

Syt4 Products(1)

mRNA	Protein	Name
NM_031693.2	NP_113881.1	synaptotagmin-4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SNARE binding	IDA IDA: Inferred from direct assay	18508778	RGD
enables SNARE binding	IPI IPI: Inferred from physical interaction	20688915	RGD
NOT enables calcium ion binding	IDA IDA: Inferred from direct assay	15311271	RGD
NOT enables calcium-dependent phospholipid binding	IDA IDA: Inferred from direct assay	7791877	RGD
enables clathrin binding	IDA IDA: Inferred from direct assay	7791877	RGD
NOT enables phosphatidylserine binding	IDA IDA: Inferred from direct assay	20688915	RGD
enables phosphatidylserine binding	IDA IDA: Inferred from direct assay	18508778	RGD
NOT enables phospholipid binding	IDA IDA: Inferred from direct assay	9830048	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9830048	RGD
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	10397765	RGD
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	10397765	RGD
NOT enables syntaxin binding	IDA IDA: Inferred from direct assay	7791877	RGD
enables syntaxin binding	IPI IPI: Inferred from physical interaction	10397765	RGD
enables syntaxin-1 binding	IPI IPI: Inferred from physical interaction	10397765	RGD
enables syntaxin-3 binding	IPI IPI: Inferred from physical interaction	10397765	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in dense core granule cytoskeletal transport	IMP IMP: Inferred from mutant phenotype	29166604	RGD
involved in negative regulation of calcium ion-dependent exocytosis	IDA IDA: Inferred from direct assay	21551071	RGD
involved in negative regulation of catecholamine secretion	IGI IGI: Inferred from genetic interaction	20735850	RGD
involved in negative regulation of dense core granule exocytosis	IMP IMP: Inferred from mutant phenotype	20303854	RGD
involved in negative regulation of neurotransmitter secretion	IDA IDA: Inferred from direct assay	10397765	RGD
involved in negative regulation of vesicle fusion	IDA IDA: Inferred from direct assay	18508778	RGD
involved in regulation of endocytosis	IMP IMP: Inferred from mutant phenotype	20303854	RGD
involved in regulation of vesicle fusion	IMP IMP: Inferred from mutant phenotype	20303854	RGD
involved in secretory granule maturation	IMP IMP: Inferred from mutant phenotype	16618809	RGD
involved in vesicle fusion with vesicle	IMP IMP: Inferred from mutant phenotype	16618809	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	10646502	RGD
located in astrocyte projection	IDA IDA: Inferred from direct assay	15197251	RGD
located in axon	IMP IMP: Inferred from mutant phenotype	29166604	RGD
located in dense core granule	IDA IDA: Inferred from direct assay	10217258	RGD
located in exocytic vesicle	IDA IDA: Inferred from direct assay	10217258	RGD
located in neuron projection	IDA IDA: Inferred from direct assay	10646502	RGD
located in neuron projection terminus	IDA IDA: Inferred from direct assay	10397765	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	15197251	RGD
located in neuronal dense core vesicle	IDA IDA: Inferred from direct assay	29166604	RGD
located in neuronal dense core vesicle membrane	IDA IDA: Inferred from direct assay	30021165	RGD
located in secretory granule membrane	IDA IDA: Inferred from direct assay	16618809	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	10217258	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

synaptotagmin-4

synaptotagmin IV

sytIV

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14116	SYT4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Syt4	NCBI	NCBI:6860

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