Syt4 - synaptotagmin 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64440

Summary

Enables several functions, including phosphatidylserine binding activity; protein dimerization activity; and syntaxin binding activity. Involved in several processes, including dense core granule cytoskeletal transport; negative regulation of transport; and vesicle organization. Located in several cellular components, including astrocyte projection; neuronal cell body; and secretory vesicle. Is intrinsic component of neuronal dense core vesicle membrane. Biomarker of visual epilepsy. Orthologous to human SYT4 (synaptotagmin 4). [provided by Alliance of Genome Resources, Apr 2022]

Syt4 Products (1)

mRNA Protein Name
NM_031693.2 NP_113881.1 synaptotagmin-4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SNARE binding IDA
IDA: Inferred from direct assay
18508778 RGD
enables SNARE binding IPI
IPI: Inferred from physical interaction
20688915 RGD
NOT enables calcium ion binding IDA
IDA: Inferred from direct assay
15311271 RGD
NOT enables calcium-dependent phospholipid binding IDA
IDA: Inferred from direct assay
7791877 RGD
enables clathrin binding IDA
IDA: Inferred from direct assay
7791877 RGD
NOT enables phosphatidylserine binding IDA
IDA: Inferred from direct assay
20688915 RGD
enables phosphatidylserine binding IDA
IDA: Inferred from direct assay
18508778 RGD
NOT enables phospholipid binding IDA
IDA: Inferred from direct assay
9830048 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9830048 RGD
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
10397765 RGD
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
10397765 RGD
NOT enables syntaxin binding IDA
IDA: Inferred from direct assay
7791877 RGD
enables syntaxin binding IPI
IPI: Inferred from physical interaction
10397765 RGD
enables syntaxin-1 binding IPI
IPI: Inferred from physical interaction
10397765 RGD
enables syntaxin-3 binding IPI
IPI: Inferred from physical interaction
10397765 RGD
Biological Process GO Annotation Evidence References Source
involved in dense core granule cytoskeletal transport IMP
IMP: Inferred from mutant phenotype
29166604 RGD
involved in negative regulation of calcium ion-dependent exocytosis IDA
IDA: Inferred from direct assay
21551071 RGD
involved in negative regulation of catecholamine secretion IGI
IGI: Inferred from genetic interaction
20735850 RGD
involved in negative regulation of dense core granule exocytosis IMP
IMP: Inferred from mutant phenotype
20303854 RGD
involved in negative regulation of neurotransmitter secretion IDA
IDA: Inferred from direct assay
10397765 RGD
involved in negative regulation of vesicle fusion IDA
IDA: Inferred from direct assay
18508778 RGD
involved in regulation of endocytosis IMP
IMP: Inferred from mutant phenotype
20303854 RGD
involved in regulation of vesicle fusion IMP
IMP: Inferred from mutant phenotype
20303854 RGD
involved in secretory granule maturation IMP
IMP: Inferred from mutant phenotype
16618809 RGD
involved in vesicle fusion with vesicle IMP
IMP: Inferred from mutant phenotype
16618809 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
10646502 RGD
located in astrocyte projection IDA
IDA: Inferred from direct assay
15197251 RGD
located in axon IMP
IMP: Inferred from mutant phenotype
29166604 RGD
located in dense core granule IDA
IDA: Inferred from direct assay
10217258 RGD
located in exocytic vesicle IDA
IDA: Inferred from direct assay
10217258 RGD
located in neuron projection IDA
IDA: Inferred from direct assay
10646502 RGD
located in neuron projection terminus IDA
IDA: Inferred from direct assay
10397765 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15197251 RGD
located in neuronal dense core vesicle IDA
IDA: Inferred from direct assay
29166604 RGD
located in neuronal dense core vesicle membrane IDA
IDA: Inferred from direct assay
30021165 RGD
located in secretory granule membrane IDA
IDA: Inferred from direct assay
16618809 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
10217258 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

synaptotagmin-4

  • synaptotagmin IV

  • sytIV

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14116 SYT4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Syt4 NCBI NCBI:6860