HAND2 - Hand2 heart and neural crest derivatives expressed 2 Gene

Rattus norvegicus

Gene ID: 64637 | Gene type: protein coding

About HAND2

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and DNA-binding transcription factor binding activity. Involved in cellular response to organic cyclic compound; cellular response to retinoic acid; and heart development. Located in nucleus. Orthologous to human HAND2 (heart and neural crest derivatives expressed 2). [provided by Alliance of Genome Resources, Apr 2022]

HAND2 Products(1)

mRNA	Protein	Name
NM_022696.2	NP_073187.1	heart- and neural crest derivatives-expressed protein 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	11994297	RGD
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	11994297	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15486975	RGD
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	11994297	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	11073966	RGD
involved in cellular response to retinoic acid	IEP IEP: Inferred from expression pattern	16619265	RGD
involved in heart development	IEP IEP: Inferred from expression pattern	15486975	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

heart- and neural crest derivatives-expressed protein 2

dHand protein	deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2
heart and neural crest derivatives expressed transcript 2	heart- and neural crest derivatives-expressed protein 2-like

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-177787A	2'-Deoxy-N-methyl-AMP ammonium		/	Unkown
HY-RS05997	HAND2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174480	Mouse Hand2 mRNA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	HAND2	NCBI	NCBI:9464

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