NUCKS1 - nuclear casein kinase and cyclin dependent kinase substrate 1 Gene

Also Known as JC7; NUCKS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64710

About NUCKS1

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:205,712,822-205,750,182 (from NCBI)

This gene has 2 transcripts (splice variants), 218 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 77.7), thyroid (RPKM 69.9) and 25 other tissues.

Summary

This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for Casein Kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by CDK1 during Mitosis of the cell cycle. [provided by RefSeq, Aug 2010]

NUCKS1 Products (1)

mRNA	Protein	Name
NM_022731.5	NP_073568.2	nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	25116364	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	26323318	GOA
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	26323318	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	25116364	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to X-ray	IMP IMP: Inferred from mutant phenotype	26323318	GOA
involved in double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	26323318	GOA
involved in interstrand cross-link repair	IMP IMP: Inferred from mutant phenotype	26323318	GOA
involved in modulation by host of RNA binding by virus	IMP IMP: Inferred from mutant phenotype	25116364	GOA
involved in modulation by host of viral RNA-binding transcription factor activity	IGI IGI: Inferred from genetic interaction	25116364	GOA
involved in modulation by host of viral genome replication	IMP IMP: Inferred from mutant phenotype	25116364	GOA
involved in positive regulation by host of viral genome replication	IMP IMP: Inferred from mutant phenotype	25116364	GOA
involved in positive regulation by host of viral transcription	IGI IGI: Inferred from genetic interaction	25116364	GOA
involved in regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	26323318	GOA
involved in regulation of DNA strand elongation	IMP IMP: Inferred from mutant phenotype	26323318	GOA
involved in replication fork processing	IDA IDA: Inferred from direct assay	26323318	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	26323318	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17604136	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11298763	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
nuclear ubiquitous casein and cyclin-dependent kinase substrate 1	P1

Related Diseases

Diseases	Alias
Breast Intraductal Proliferative Lesion	Intraductal Proliferative Lesion Intraductal Proliferative Lesion Of The Breast
Neurodegeneration, Childhood-Onset, Stress-Induced, With Variable Ataxia And Seizures	CONDSIAS Stress-Induced Childhood-Onset Neurodegeneration With Variable Ataxia And Seizures
Scoliosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09656	NUCKS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NUCKS1	VGNC	VGNC:75490
Felis catus	NUCKS1	VGNC	VGNC:97540
Mus musculus	NUCKS1	MGD	MGI:1934811
Rattus norvegicus	NUCKS1	RGD	RGD:620993
Bos taurus	NUCKS1	VGNC	VGNC:32320
Canis familiaris	NUCKS1	VGNC	VGNC:53125