ETNPPL - ethanolamine-phosphate phospho-lyase Gene

Also Known as AGXT2L1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64850

About ETNPPL

Cytogenetic location: 4q25 Genomic coordinates (GRCh38): 4:108,742,053-108,763,053 (from NCBI)

This gene has 10 transcripts (splice variants), 195 orthologues and 4 paralogues. Biased expression in liver (RPKM 37.5), brain (RPKM 36.7) and 3 other tissues.

Summary

Enables ethanolamine-phosphate phospho-lyase activity. Predicted to be located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]

ETNPPL Products (6)

mRNA Protein Name
NM_001146590.2 NP_001140062.1 ethanolamine-phosphate phospho-lyase isoform 2
NM_001146627.2 NP_001140099.1 ethanolamine-phosphate phospho-lyase isoform 3
NM_001331031.2 NP_001317960.1 ethanolamine-phosphate phospho-lyase isoform 4
NM_001331032.2 NP_001317961.1 ethanolamine-phosphate phospho-lyase isoform 4
NM_001331033.2 NP_001317962.1 ethanolamine-phosphate phospho-lyase isoform 5
NM_031279.4 NP_112569.2 ethanolamine-phosphate phospho-lyase isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables ethanolamine-phosphate phospho-lyase activity IDA
IDA: Inferred from direct assay
22241472 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ETNPPL Protein Structure

Aminotran_3

Aminotran_3: Aminotransferase class-III (33 - 373)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 499 a.a.
Protein Preferred Names Protein Names

ethanolamine-phosphate phospho-lyase

  • alanine--glyoxylate aminotransferase 2-like 1

ETNPPL Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ETNPPL Q8TBG4 ZC3HC1 Homo sapiens Q86WB0
Anti Tag CoIP
33961781
Intra
ETNPPL Q8TBG4 ZC3HC1 Homo sapiens Q86WB0
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Alcohol Dependence

  • Alcoholism

  • Alcohol Dependence, Susceptibility To

  • Alcohol Dependence, Protection Against

  • Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

  • Alcoholism, Susceptibility To

  • Alcoholic Intoxication, Chronic

  • Pharyngeal Neoplasms

  • Chronic Alcoholism

  • Dipsomania

  • Alcohol Addiction

  • Ethanol Dependence

  • Chronic Ethanolism

  • Chronic Alcoholic Disease Nos

  • Alcoholic Disease Nos

  • Alcoholic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04561 ETNPPL Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ETNPPL VGNC VGNC:53712
Canis familiaris ETNPPL VGNC VGNC:97193
Rattus norvegicus ETNPPL RGD RGD:1590098
Mus musculus ETNPPL MGD MGI:1919010
Felis catus ETNPPL VGNC VGNC:78488
Macaca mulatta ETNPPL VGNC VGNC:81399
Others ETNPPL NCBI