HTR7 - 5-hydroxytryptamine receptor 7 Gene

Also Known as 5Ht7

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 65032

About HTR7

Primary_assembly 1: 233,636,452-233,760,626 reverse strand.mRatBN7.2:CM026974.1

This gene has 6 transcripts (splice variants), 221 orthologues, 8 paralogues and is associated with 24 phenotypes. Biased expression in Brain (RPKM 28.7), Spleen (RPKM 13.2) and 8 other tissues.

Summary

Enables G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Involved in several processes, including adenylate cyclase-activating serotonin receptor signaling pathway; detection of mechanical stimulus involved in sensory perception of pain; and modulation of chemical synaptic transmission. Located in several cellular components, including neuronal cell body; rough endoplasmic reticulum; and synaptic vesicle. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study amnestic disorder; anxiety disorder; childhood absence epilepsy; cognitive disorder; and migraine. Biomarker of irritable bowel syndrome. Human ortholog(s) of this gene implicated in alcohol use disorder. Orthologous to human HTR7 (5-hydroxytryptamine receptor 7). [provided by Alliance of Genome Resources, Apr 2022]

HTR7 Products (1)

mRNA Protein Name
NM_022938.2 NP_075227.1 5-hydroxytryptamine receptor 7

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled serotonin receptor activity IDA
IDA: Inferred from direct assay
8394362 RGD
enables neurotransmitter receptor activity IDA
IDA: Inferred from direct assay
8394362 RGD
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-activating serotonin receptor signaling pathway IDA
IDA: Inferred from direct assay
8394362 RGD
involved in behavioral response to pain IMP
IMP: Inferred from mutant phenotype
16098671 RGD
involved in detection of mechanical stimulus involved in sensory perception of pain IDA
IDA: Inferred from direct assay
21843960 RGD
involved in dopaminergic neuron differentiation IMP
IMP: Inferred from mutant phenotype
17443768 RGD
involved in long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
22314569 RGD
involved in memory IMP
IMP: Inferred from mutant phenotype
18308404 RGD
involved in negative regulation of serotonin secretion IMP
IMP: Inferred from mutant phenotype
15260125 RGD
involved in positive regulation of neuron projection development IDA
IDA: Inferred from direct assay
19243449 RGD
involved in presynaptic modulation of chemical synaptic transmission EXP
EXP: Inferred from Experiment
26779891 RGD
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
26779891 RGD
involved in regulation of vein smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
31125290 RGD
involved in response to corticosterone IDA
IDA: Inferred from direct assay
19617650 RGD
involved in response to electrical stimulus IEP
IEP: Inferred from expression pattern
18195451 RGD
involved in serotonin receptor signaling pathway IDA
IDA: Inferred from direct assay
8394362 RGD
involved in urinary bladder smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
20969855 RGD
Cellular Component GO Annotation Evidence References Source
located in axon terminus IDA
IDA: Inferred from direct assay
16082681 RGD
located in dendrite IDA
IDA: Inferred from direct assay
16082681 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
16082681 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
16082681 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
16082681 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
16082681 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HTR7 Protein Structure

7tmA_5-HT7

7tmA_5-HT7: cd15329 (99 - 397)

7tmA_5-HT7

7tmA_5-HT7: cd15329 (118 - 144)

7tmA_5-HT7

7tmA_5-HT7: cd15329 (157 - 187)

7tmA_5-HT7

7tmA_5-HT7: cd15329 (199 - 221)

7tmA_5-HT7

7tmA_5-HT7: cd15329 (238 - 267)

7tmA_5-HT7

7tmA_5-HT7: cd15329 (322 - 352)

7tmA_5-HT7

7tmA_5-HT7: cd15329 (365 - 390)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 508 a.a.
Protein Preferred Names Protein Names

5-hydroxytryptamine receptor 7

  • 5-HT-7

  • 5-HT-X

  • 5-HT7

  • 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled

  • GPRFO

  • high affinity serotonin receptor (5HT7)

  • serotonin receptor 7

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06483 HTR7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06484 Htr7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06485 HTR7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens HTR7 NCBI NCBI:3363