HTR7 - 5-hydroxytryptamine receptor 7 Gene

Also Known as 5-HT7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3363

About HTR7

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:90,740,823-90,858,039 (from NCBI)

This gene has 3 transcripts (splice variants), 221 orthologues and 8 paralogues. Biased expression in testis (RPKM 6.1), urinary bladder (RPKM 2.0) and 8 other tissues.

Summary

The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and Other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008]

HTR7 Products (4)

mRNA	Protein	Name
NM_019860.4	NP_062874.1	5-hydroxytryptamine receptor 7 isoform b
XM_024447973.2	XP_024303741.1	5-hydroxytryptamine receptor 7 isoform X1
NM_000872.5	NP_000863.1	5-hydroxytryptamine receptor 7 isoform a
NM_019859.4	NP_062873.1	5-hydroxytryptamine receptor 7 isoform d

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled serotonin receptor activity	IDA IDA: Inferred from direct assay	8226867	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19486527	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adenylate cyclase-activating serotonin receptor signaling pathway	IDA IDA: Inferred from direct assay	8226867	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	22448645	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HTR7 Protein Structure

7tm_1

0
100
200
300
400
479 a.a.

Protein Preferred Names	Protein Names
5-hydroxytryptamine receptor 7	5-HT-7 5-HT-X 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)

HTR7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HTR7	P34969	MATR3	Homo sapiens	P43243	TAP	19486527
Intra	HTR7	P34969	MATR3	Homo sapiens	P43243	Crosslink	30021884

Cross: Cross-species interaction Intra: Intraspecies interaction

HTR7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83051	HTR7 Antibody (YA2796)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Irritable Bowel Syndrome	Irritable Colon Psychogenic Ibs Ibs - [Irritable Bowel Syndrome] Spastic Bowel Syndrome
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Severe Congenital Neutropenia 8	Autosomal Dominant Severe Congenital Neutropenia 8 With Or Without Pancreatic Dysfunction And/Or Neurological Abnormalities Scn8 Sdsl Shwachman-Diamond Syndrome-Like
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Psychotic Disorder	Psychotic Disorders Mental Or Behavioural Disorder Psychotic Mental Disorders
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Hymenolepiasis	Dwarf Tapeworm Infection Hymenolepis Infectious Disease Hymenolepsis Infection Hyemolepis Nana Infection Hymenolepiosis Hymenolepis Infection Dwarf Tapeworm Hymenolepidosis Hymenolepis Infestation
Acute Closed-Angle Glaucoma	Acute Angle-Closure Glaucoma
Oculogyric Crisis
Mental Depression	Depression Depressive Disorder
Ischemic Colitis	Colitis, Ischemic Irreversible Ischaemic Colitis
Bipolar I Disorder	Manic Depression Nos Manic-Depressive Illness Bipolar Disorder Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06483	HTR7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06484	Htr7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06485	HTR7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HTR7	VGNC	VGNC:30003
Rattus norvegicus	HTR7	RGD	RGD:71034
Mus musculus	HTR7	MGD	MGI:99841
Macaca mulatta	HTR7	VGNC	VGNC:106061
Felis catus	HTR7	VGNC	VGNC:67677
Canis familiaris	HTR7	VGNC	VGNC:41834
Others	HTR7	NCBI