2. Gene
  3. Tmed2 - transmembrane p24 trafficking protein 2 Gene

Tmed2 - transmembrane p24 trafficking protein 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Rnp24

Gene ID: 65165 | Gene type: protein coding

About Tmed2

Summary

Predicted to be involved in several processes, including negative regulation of GTPase activity; placenta development; and protein localization to plasma membrane. Predicted to act upstream of or within several processes, including PERK-mediated unfolded protein response; chordate embryonic development; and regulation of gene expression. Located in COPI-coated vesicle and zymogen granule membrane. Is integral component of membrane. Orthologous to human TMED2 (transmembrane p24 trafficking protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Tmed2 Products(2)

mRNA Protein Name
NM_001393805.1 NP_001380734.1 transmembrane emp24 domain-containing protein 2 isoform 1 precursor
NM_031722.3 NP_113910.1 transmembrane emp24 domain-containing protein 2 isoform 2 precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11739402 RGD
Cellular Component GO Annotation Evidence Reference Source
located in COPI-coated vesicle IDA
IDA: Inferred from direct assay
10214941 RGD
located in membrane IDA
IDA: Inferred from direct assay
8663407 RGD
located in zymogen granule membrane IDA
IDA: Inferred from direct assay
8663407 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transmembrane emp24 domain-containing protein 2

COPI-coated vesicle membrane protein p24

RNP21.4

coated vesicle membrane protein

membrane protein p24A

p24 family protein beta-1

p24beta1

transmembrane emp24 domain trafficking protein 2

Tmed2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Tmed2 Q63524 F2rl1 Rattus norvegicus Q63645
Anti Bait CoIP
17693410
Intra
Tmed2 Q63524 Gorasp1 Rattus norvegicus O35254
Y2H
11739402
Intra
Tmed2 Q63524 Gorasp2 Rattus norvegicus Q9R064
Pull Down
11739402
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14636 TMED2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21788 Tmed2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tmed2 NCBI NCBI:10959