Kcnh1 - potassium voltage-gated channel subfamily H member 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 65198

Summary

Enables several functions, including 14-3-3 protein binding activity; Calmodulin binding activity; and delayed rectifier Potassium Channel activity. Involved in cellular response to calcium ion; potassium ion transmembrane transport; and startle response. Located in several cellular components, including axolemma; nuclear inner membrane; and presynaptic membrane. Is integral component of plasma membrane. Part of Potassium Channel complex. Is integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human KCNH1 (potassium voltage-gated channel subfamily H member 1). [provided by Alliance of Genome Resources, Apr 2022]

Kcnh1 Products (1)

mRNA Protein Name
NM_031742.3 NP_113930.1 potassium voltage-gated channel subfamily H member 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 14-3-3 protein binding IPI
IPI: Inferred from physical interaction
22911758 RGD
enables calmodulin binding IDA
IDA: Inferred from direct assay
27516594 RGD
enables delayed rectifier potassium channel activity IDA
IDA: Inferred from direct assay
27516594 RGD
enables identical protein binding IDA
IDA: Inferred from direct assay
21646358 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9722534 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
11834728 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
25008323 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
25008323 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to calcium ion IDA
IDA: Inferred from direct assay
8790430 RGD
involved in monoatomic ion transmembrane transport IDA
IDA: Inferred from direct assay
24495567 RGD
involved in potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
7925287 RGD
involved in potassium ion transport IDA
IDA: Inferred from direct assay
31490124 RGD
involved in startle response IMP
IMP: Inferred from mutant phenotype
24284010 RGD
Cellular Component GO Annotation Evidence References Source
located in axolemma IDA
IDA: Inferred from direct assay
20111597 RGD
located in axon IDA
IDA: Inferred from direct assay
24495567 RGD
located in cell surface IDA
IDA: Inferred from direct assay
21646358 RGD
located in dendrite IDA
IDA: Inferred from direct assay
24495567 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
24495567 RGD
located in nuclear inner membrane IDA
IDA: Inferred from direct assay
21559285 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
18650019 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
27516594 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
24495567 RGD
is active in postsynaptic density membrane IMP
IMP: Inferred from mutant phenotype
24495567 RGD
part of potassium channel complex IDA
IDA: Inferred from direct assay
27516594 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
25556795 RGD
located in presynaptic membrane IDA
IDA: Inferred from direct assay
20111597 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily H member 1

  • EAG channel 1

  • EAG1

  • ether-a-go-go potassium channel 1

  • potassium channel, voltage gated eag related subfamily H, member 1

  • potassium voltage-gated channel, subfamily H (eag-related), member 1

  • r-eag

  • voltage-gated potassium channel subunit Kv10.1

Kcnh1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Kcnh1 Q63472 Rabep1 Rattus norvegicus O35550
Anti Bait CoIP
22841712
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07125 KCNH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnh1 NCBI NCBI:3756