Kcnh1 - potassium voltage-gated channel subfamily H member 1 Gene

Rattus norvegicus

Gene ID: 65198 | Gene type: protein coding

About Kcnh1

Summary

Enables several functions, including 14-3-3 protein binding activity; Calmodulin binding activity; and delayed rectifier Potassium Channel activity. Involved in cellular response to calcium ion; potassium ion transmembrane transport; and startle response. Located in several cellular components, including axolemma; nuclear inner membrane; and presynaptic membrane. Is integral component of plasma membrane. Part of Potassium Channel complex. Is integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human KCNH1 (potassium voltage-gated channel subfamily H member 1). [provided by Alliance of Genome Resources, Apr 2022]

Kcnh1 Products(1)

mRNA	Protein	Name
NM_031742.3	NP_113930.1	potassium voltage-gated channel subfamily H member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 14-3-3 protein binding	IPI IPI: Inferred from physical interaction	22911758	RGD
enables calmodulin binding	IDA IDA: Inferred from direct assay	27516594	RGD
enables delayed rectifier potassium channel activity	IDA IDA: Inferred from direct assay	27516594	RGD
enables identical protein binding	IDA IDA: Inferred from direct assay	21646358	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9722534	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	11834728	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	25008323	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	25008323	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to calcium ion	IDA IDA: Inferred from direct assay	8790430	RGD
involved in monoatomic ion transmembrane transport	IDA IDA: Inferred from direct assay	24495567	RGD
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	7925287	RGD
involved in potassium ion transport	IDA IDA: Inferred from direct assay	31490124	RGD
involved in startle response	IMP IMP: Inferred from mutant phenotype	24284010	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axolemma	IDA IDA: Inferred from direct assay	20111597	RGD
located in axon	IDA IDA: Inferred from direct assay	24495567	RGD
located in cell surface	IDA IDA: Inferred from direct assay	21646358	RGD
located in dendrite	IDA IDA: Inferred from direct assay	24495567	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	24495567	RGD
located in nuclear inner membrane	IDA IDA: Inferred from direct assay	21559285	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	18650019	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	27516594	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	24495567	RGD
is active in postsynaptic density membrane	IMP IMP: Inferred from mutant phenotype	24495567	RGD
part of potassium channel complex	IDA IDA: Inferred from direct assay	27516594	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	25556795	RGD
located in presynaptic membrane	IDA IDA: Inferred from direct assay	20111597	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

potassium voltage-gated channel subfamily H member 1

EAG channel 1	EAG1
ether-a-go-go potassium channel 1	potassium channel, voltage gated eag related subfamily H, member 1
potassium voltage-gated channel, subfamily H (eag-related), member 1	r-eag
voltage-gated potassium channel subunit Kv10.1

Kcnh1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Kcnh1	Q63472	Rabep1	Rattus norvegicus	O35550	Anti Bait CoIP	22841712

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07125	KCNH1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcnh1	NCBI	NCBI:3756

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