DYNC2H1 - Dync2h1 dynein cytoplasmic 2 heavy chain 1 Gene

Also Known as Dhc1b; Dnch2; Dnchc2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 65209

Summary

Enables dynein light intermediate chain binding activity. Predicted to be involved in Golgi organization; cilium assembly; and intraciliary retrograde transport. Predicted to act upstream of or within several processes, including animal organ development; non-motile cilium assembly; and positive regulation of smoothened signaling pathway. Predicted to be located in Golgi apparatus; apical part of cell; and microtubule. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in axoneme and motile cilium. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy 3. Orthologous to human DYNC2H1 (dynein cytoplasmic 2 heavy chain 1). [provided by Alliance of Genome Resources, Apr 2022]

DYNC2H1 Products (1)

mRNA Protein Name
NM_023024.2 NP_075413.2 cytoplasmic dynein 2 heavy chain 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables dynein light intermediate chain binding IPI
IPI: Inferred from physical interaction
12432068 RGD
Biological Process GO Annotation Evidence References Source
involved in cilium assembly IEP
IEP: Inferred from expression pattern
8832411 RGD
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
8832411 RGD
part of cytoplasmic dynein complex IDA
IDA: Inferred from direct assay
9450951 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytoplasmic dynein 2 heavy chain 1

  • cytoplasmic dynein 2 heavy chain 1-like

  • cytoplasmic dynein heavy chain 2

  • dynein heavy chain isotype 1B

  • dynein, cytoplasmic, heavy chain 2

  • dynein, cytoplasmic, heavy polypeptide 2

  • dynein-like protein 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04086 DYNC2H1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens DYNC2H1 NCBI NCBI:79659