SLC6A9 - solute carrier family 6 member 9 Gene

Also Known as GLYT1; GCENSG

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6536

About SLC6A9

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:43,996,483-44,031,462 (from NCBI)

This gene has 12 transcripts (splice variants), 207 orthologues, 19 paralogues and is associated with 4 phenotypes. Broad expression in skin (RPKM 13.4), adrenal (RPKM 9.7) and 18 other tissues.

Summary

The amino acid glycine acts as an inhibitory neurotransmitter in the central nervous system. The protein encoded by this gene is one of two transporters that stop glycine signaling by removing it from the synaptic cleft. [provided by RefSeq, Jun 2016]

SLC6A9 Products (16)

mRNA Protein Name
NM_001328628.1 NP_001315557.1 sodium- and chloride-dependent glycine transporter 1 isoform 7
XM_047428739.1 XP_047284695.1 sodium- and chloride-dependent glycine transporter 1 isoform X1
NM_001328626.2 NP_001315555.1 sodium- and chloride-dependent glycine transporter 1 isoform 5
XM_017002152.3 XP_016857641.1 sodium- and chloride-dependent glycine transporter 1 isoform X4
XM_047428744.1 XP_047284700.1 sodium- and chloride-dependent glycine transporter 1 isoform X6
XM_047428740.1 XP_047284696.1 sodium- and chloride-dependent glycine transporter 1 isoform X2
NM_001328630.2 NP_001315559.1 sodium- and chloride-dependent glycine transporter 1 isoform 8
XM_011542017.3 XP_011540319.1 sodium- and chloride-dependent glycine transporter 1 isoform X3
NM_201649.4 NP_964012.2 sodium- and chloride-dependent glycine transporter 1 isoform 2
NR_048548.2
NM_001328627.1 NP_001315556.1 sodium- and chloride-dependent glycine transporter 1 isoform 6
XM_047428743.1 XP_047284699.1 sodium- and chloride-dependent glycine transporter 1 isoform X5
NM_001024845.3 NP_001020016.1 sodium- and chloride-dependent glycine transporter 1 isoform 3
NM_001328629.1 NP_001315558.1 sodium- and chloride-dependent glycine transporter 1 isoform 3
NM_006934.4 NP_008865.2 sodium- and chloride-dependent glycine transporter 1 isoform 1
NM_001261380.2 NP_001248309.1 sodium- and chloride-dependent glycine transporter 1 isoform 4

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glycine:sodium symporter activity IDA
IDA: Inferred from direct assay
8183239 GOA
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
11159884 GOA
located in basal plasma membrane IDA
IDA: Inferred from direct assay
11159884 GOA
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
11159884 GOA
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
11159884 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC6A9 Protein Structure

SNF

SNF: Sodium:neurotransmitter symporter family (100 - 634)

  • 0
  • 200
  • 400
  • 600
  • 706 a.a.
Protein Preferred Names Protein Names

sodium- and chloride-dependent glycine transporter 1

  • glyT-1

  • solute carrier family 6 (neurotransmitter transporter, glycine), member 9

Related Diseases

Diseases Alias
Glycine Encephalopathy

  • Non-Ketotic Hyperglycinemia

  • Nonketotic Hyperglycinemia

  • NKH

  • GCE

  • Hyperglycinemia, Nonketotic

  • Hyperglycinemia Nonketotic

  • Infantile Glycine Encephalopathy

  • Encephalopathy, Glycine

  • Glycine Synthase Deficiency

  • Nka

  • Neonatal Glycine Encephalopathy

  • Classic Glycine Encephalopathy

  • Neonatal Nkh

  • Neonatal Non-Ketotic Hyperglycinemia

  • Infantile Nkh

  • Infantile Non-Ketotic Hyperglycinemia

  • Non-Ketotic Hyperglycinaemia

  • Glycine Cleavage Deficiency

  • Nonketotic Hyperglycinaemia
Hartnup Disorder

  • Hartnup Disease

  • HND

  • Neutral 1 Amino Acid Transport Defect

  • Neutral Amino Acid Transport Defect

  • Deficiency Of Tryptophan Oxygenase

  • Hartnup'S Disease

  • Aminoaciduria, Hartnup Type

  • Disorder Of Neutral Amino Acid Transport
Hyperekplexia

  • Hereditary Hyperekplexia

  • Kok Disease

  • Congenital Stiff Man Syndrome

  • Familial Startle Disease

  • Sthe

  • Stiff-Baby Syndrome

  • Hereditary Hyperexplexia

  • Startle Disease

  • Exaggerated Startle Reaction

  • Hyperexplexia Hereditary

  • Startle Disease, Familial

  • Startle Reaction, Exaggerated

  • Stiff-Man Syndrome, Congenital

  • Stiff-Person Syndrome, Congenital

  • Congenital Stiff-Man Syndrome

  • Congenital Stiff-Person Syndrome

  • Familial Hyperekplexia

  • Startle Syndrome

  • Stiff Baby Syndrome

  • Hyperekplexia, Hereditary

  • Stiff-Person Syndrome
Iminoglycinuria

  • Iminoglycinuria, Digenic

  • IG
Hyperekplexia 3

  • HKPX3

  • Hyperekplexia, Type 3
Atypical Glycine Encephalopathy

  • Atypical Nka

  • Atypical Non-Ketotic Hyperglycinemia
Retinitis Pigmentosa 68

  • RP68

  • Retinitis Pigmentosa, Type 68
Psychotic Disorder

  • Psychotic Disorders

  • Mental Or Behavioural Disorder

  • Psychotic

  • Mental Disorders
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Glycine Encephalopathy With Normal Serum Glycine

  • GCENSG

  • Encephalopathy, Glycine, With Normal Serum Glycine
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13320 SLC6A9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13321 Slc6a9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13322 Slc6a9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SLC6A9 VGNC VGNC:65420
Canis familiaris SLC6A9 VGNC VGNC:46469
Mus musculus SLC6A9 MGD MGI:95760
Rattus norvegicus SLC6A9 RGD RGD:621243
Macaca mulatta SLC6A9 VGNC VGNC:77625
Others SLC6A9 NCBI