2. Gene
  3. SLC6A9 - solute carrier family 6 member 9 Gene

SLC6A9 - solute carrier family 6 member 9 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GLYT1; GCENSG

Gene ID: 6536 | Gene type: protein coding

About SLC6A9

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:43,996,483-44,031,462 (from NCBI)

This gene has 12 transcripts (splice variants), 207 orthologues, 19 paralogues and is associated with 4 phenotypes. Broad expression in skin (RPKM 13.4), adrenal (RPKM 9.7) and 18 other tissues.

Summary

The amino acid glycine acts as an inhibitory neurotransmitter in the central nervous system. The protein encoded by this gene is one of two transporters that stop glycine signaling by removing it from the synaptic cleft. [provided by RefSeq, Jun 2016]

SLC6A9 Products(16)

mRNA Protein Name
NM_001328628.1 NP_001315557.1 sodium- and chloride-dependent glycine transporter 1 isoform 7
XM_047428739.1 XP_047284695.1 sodium- and chloride-dependent glycine transporter 1 isoform X1
NM_001328626.2 NP_001315555.1 sodium- and chloride-dependent glycine transporter 1 isoform 5
XM_017002152.3 XP_016857641.1 sodium- and chloride-dependent glycine transporter 1 isoform X4
XM_047428744.1 XP_047284700.1 sodium- and chloride-dependent glycine transporter 1 isoform X6
XM_047428740.1 XP_047284696.1 sodium- and chloride-dependent glycine transporter 1 isoform X2
NM_001328630.2 NP_001315559.1 sodium- and chloride-dependent glycine transporter 1 isoform 8
XM_011542017.3 XP_011540319.1 sodium- and chloride-dependent glycine transporter 1 isoform X3
NM_201649.4 NP_964012.2 sodium- and chloride-dependent glycine transporter 1 isoform 2
NR_048548.2
NM_001328627.1 NP_001315556.1 sodium- and chloride-dependent glycine transporter 1 isoform 6
XM_047428743.1 XP_047284699.1 sodium- and chloride-dependent glycine transporter 1 isoform X5
NM_001024845.3 NP_001020016.1 sodium- and chloride-dependent glycine transporter 1 isoform 3
NM_001328629.1 NP_001315558.1 sodium- and chloride-dependent glycine transporter 1 isoform 3
NM_006934.4 NP_008865.2 sodium- and chloride-dependent glycine transporter 1 isoform 1
NM_001261380.2 NP_001248309.1 sodium- and chloride-dependent glycine transporter 1 isoform 4

SLC6A9 Protein Structure

SNF

SNF: Sodium:neurotransmitter symporter family (100 - 634)

  • 0
  • 200
  • 400
  • 600
  • 706 a.a.
Protein Preferred Names Protein Names

sodium- and chloride-dependent glycine transporter 1

glyT-1

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

Related Diseases

Diseases Alias
Glycine Encephalopathy

Non-Ketotic Hyperglycinemia

Nonketotic Hyperglycinemia

NKH

GCE

Hyperglycinemia, Nonketotic

Hyperglycinemia Nonketotic

Infantile Glycine Encephalopathy

Encephalopathy, Glycine

Glycine Synthase Deficiency

Nka

Neonatal Glycine Encephalopathy

Classic Glycine Encephalopathy

Neonatal Nkh

Neonatal Non-Ketotic Hyperglycinemia

Infantile Nkh

Infantile Non-Ketotic Hyperglycinemia

Non-Ketotic Hyperglycinaemia

Glycine Cleavage Deficiency

Nonketotic Hyperglycinaemia
Hartnup Disorder

Hartnup Disease

HND

Neutral 1 Amino Acid Transport Defect

Neutral Amino Acid Transport Defect

Deficiency Of Tryptophan Oxygenase

Hartnup'S Disease

Aminoaciduria, Hartnup Type

Disorder Of Neutral Amino Acid Transport
Hyperekplexia

Hereditary Hyperekplexia

Kok Disease

Congenital Stiff Man Syndrome

Familial Startle Disease

Sthe

Stiff-Baby Syndrome

Hereditary Hyperexplexia

Startle Disease

Exaggerated Startle Reaction

Hyperexplexia Hereditary

Startle Disease, Familial

Startle Reaction, Exaggerated

Stiff-Man Syndrome, Congenital

Stiff-Person Syndrome, Congenital

Congenital Stiff-Man Syndrome

Congenital Stiff-Person Syndrome

Familial Hyperekplexia

Startle Syndrome

Stiff Baby Syndrome

Hyperekplexia, Hereditary

Stiff-Person Syndrome
Iminoglycinuria

Iminoglycinuria, Digenic

IG
Hyperekplexia 3

HKPX3

Hyperekplexia, Type 3
Atypical Glycine Encephalopathy

Atypical Nka

Atypical Non-Ketotic Hyperglycinemia
Retinitis Pigmentosa 68

RP68

Retinitis Pigmentosa, Type 68
Psychotic Disorder

Psychotic Disorders

Mental Or Behavioural Disorder

Psychotic

Mental Disorders
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Glycine Encephalopathy With Normal Serum Glycine

GCENSG

Encephalopathy, Glycine, With Normal Serum Glycine
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13320 SLC6A9 Human Pre-designed siRNA Set A / Unkown
HY-RS13321 Slc6a9 Mouse Pre-designed siRNA Set A / Unkown
HY-RS13322 Slc6a9 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SLC6A9 VGNC VGNC:65420
Canis familiaris SLC6A9 VGNC VGNC:46469
Mus musculus SLC6A9 MGD MGI:95760
Rattus norvegicus SLC6A9 RGD RGD:621243
Macaca mulatta SLC6A9 VGNC VGNC:77625