SLC7A4 - solute carrier family 7 member 4 Gene

Homo sapiens

Also known as VH; CAT4; CAT-4; HCAT3

Gene ID: 6545 | Gene type: protein coding

About SLC7A4

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:21,028,718-21,032,561 (from NCBI)

This gene has 3 transcripts (splice variants), 265 orthologues and 12 paralogues. Biased expression in testis (RPKM 11.6), esophagus (RPKM 3.0) and 12 other tissues.

Summary

Predicted to enable amino acid transmembrane transporter activity. Predicted to be involved in amino acid transport. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC7A4 Products(1)

mRNA	Protein	Name
NM_004173.3	NP_004164.2	cationic amino acid transporter 4

SLC7A4 Protein Structure

AA_permease_2

AA_permease_C

0
100
200
300
400
500
635 a.a.

Protein Preferred Names

Protein Names

cationic amino acid transporter 4

Ig heavy chain variable region

Related Diseases

Diseases

Alias

Velocardiofacial Syndrome

Shprintzen Syndrome	VCFS
Chromosome 22q11.2 Deletion Syndrome	Vcf Syndrome
Shprintzen Vcf Syndrome	Vcf-Velocardiofacial Syndrome
Velo-Cardio-Facial Syndrome	Digeorge Syndrome
22q11 Deletion Syndrome	Conotruncal Anomaly Face Syndrome

Rubeosis Iridis

Breast Apocrine Carcinoma

Apocrine Carcinoma Of Breast

Apocrine Breast Carcinoma

Chromophobe Adenoma

Adenoma, Chromophobe	Chromophobe Adenoma Of The Pituitary Gland
Adenoma Chromophobe

Heparin Cofactor Ii Deficiency

Thrombophilia Due To Heparin Cofactor Ii Deficiency	THPH10
Hcf Ii Deficiency	Hcf2 Deficiency
Thrombophilia 10 Due To Heparin Cofactor Ii Deficiency	Hcf 2 Deficiency
Thrombophilia Due To Heparin Cofactor 2 Deficiency	Thrombophilia, Due To Heparin Cofactor Ii Deficiency

Vestibular Nystagmus

Nystagmus Associated With Disorder Of The Vestibular System

Spondylolysis

Acquired Spondylolysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13330	SLC7A4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SLC7A4	VGNC	VGNC:108056
Felis catus	SLC7A4	VGNC	VGNC:65426
Rattus norvegicus	SLC7A4	RGD	RGD:1305905
Bos taurus	SLC7A4	VGNC	VGNC:34930
Mus musculus	SLC7A4	MGD	MGI:2146512
Canis familiaris	SLC7A4	VGNC	VGNC:46475

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