SLCO2A1 - solute carrier organic anion transporter family member 2A1 Gene

Also Known as PGT; MATR1; PHOAD; PHOAR2; OATP2A1; SLC21A2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6578

About SLCO2A1

Cytogenetic location: 3q22.1-q22.2 Genomic coordinates (GRCh38): 3:133,932,701-134,029,925 (from NCBI)

This gene has 8 transcripts (splice variants), 215 orthologues, 10 paralogues and is associated with 4 phenotypes. Broad expression in lung (RPKM 28.3), thyroid (RPKM 27.0) and 20 other tissues.

Summary

This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues. [provided by RefSeq, Dec 2011]

SLCO2A1 Products (1)

mRNA	Protein	Name
NM_005630.3	NP_005621.2	solute carrier organic anion transporter family member 2A1

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	References	Source
located in basal plasma membrane	IDA IDA: Inferred from direct assay	35307651	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLCO2A1 Protein Structure

OATP

Kazal_2

0
100
200
300
400
500
600
643 a.a.

Protein Preferred Names	Protein Names
solute carrier organic anion transporter family member 2A1	matrin F/G 1

Related Diseases

Diseases	Alias
Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 2	PHOAR2 Pachydermoperiostosis, Autosomal Recessive Pdp, Autosomal Recessive Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 2 Osteoarthropathy, Hypertrophic, Primary, Autosomal Recessive, Type 2
Hypertrophic Osteoarthropathy, Primary, Autosomal Dominant	PHOAD Pho, Autosomal Dominant Pachydermoperiostosis, Autosomal Dominant Pdp, Autosomal Dominant
Chronic Enteropathy Associated With Slco2a1 Gene	Ceas
Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1	Cranioosteoarthropathy PHOAR1 Pachydermoperiostosis, Autosomal Recessive Touraine-Solente-Gole Syndrome Pho, Autosomal Recessive Pdp, Autosomal Recessive Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 Cranio Osteoarthropathy Cranio-Osteoarthropathy Currarino Disease Currarino Idiopathic Osteoarthropathy Reginato-Schiapachasse Syndrome Touraine-Solente-Golé Syndrome COA Pachydermoperiostosis Autosomal Recessive Pdp Autosomal Recessive Pho Autosomal Recessive Osteoarthropathy, Hypertrophic, Primary, Autosomal Recessive, Type 1 Osteoarthropathy, Primary Hypertrophic Reginato Schiapachasse Syndrome
Acromegaloid Changes, Cutis Verticis Gyrata, And Corneal Leukoma	Pachydermoperiostosis Rosenthal-Kloepfer Syndrome Pdp Acromegaloid Changes, Cutis Verticis Gyrata And Corneal Leukoma Idiopathic Hypertrophic Osteoarthropathy Primary Hypertrophic Osteoarthropathy Touraine Solente Gole Syndrome Touraine-Solente-Gole Syndrome
Primary Hypertrophic Osteoarthropathy	Pachydermoperiostosis Syndrome Osteoarthropathy, Primary Hypertrophic Pachydermoperiostosis Of Nail Idiopathic Hypertrophic Osteoarthropathy Pho
Acroosteolysis	Acro-Osteolysis
Secondary Hypertrophic Osteoarthropathy	Osteoarthropathy, Secondary Hypertrophic Bamberger-Marie Disease Hpoa - Hypertrophic Pulmonary Osteoarthropathy Hypertrophic Pulmonary Osteoarthropathy Marie Bamberger Disease
Outlet Dysfunction Constipation
Ventriculomegaly With Cystic Kidney Disease	VMCKD Cystic Kidney Disease With Ventriculomegaly Ventriculomegaly-Cystic Kidney Disease Ventriculomegaly - Cystic Kidney Disease Congenital Nephrosis-Cerebral Ventriculomegaly Syndrome
Spinocerebellar Ataxia, Autosomal Recessive 6	SCAR6 Norwegian Infantile Onset Ataxia Autosomal Recessive Spinocerebellar Ataxia 6 Autosomal Recessive Spinocerebellar Ataxia Type 6 Infantile-Onset Autosomal Recessive Nonprogressive Cerebellar Ataxia Cerebellar Ataxia, Infantile Nonprogressive, Autosomal Recessive Spinocerebellar Ataxia Autosomal Recessive 6 Cerebellar Ataxia Infantile Nonprogressive Autosomal Recessive
Hypokalemia	Potassium Deficiency Potassium Deficiency Disorder Hypopotassemia Potassium Potassium [K] Deficiency Hypokalaemic Syndrome Hypopotassaemia Hypopotassaemia Syndrome Hypokalaemic Potassium Depletion
Congenital Heart Defects, Dysmorphic Facial Features, And Intellectual Developmental Disorder	CHDFIDD Cdk13-Related Disorder Cdk13-Related Chdfidd Cdk13-Related Congenital Heart Defects, Dysmorphic Facial Features, Intellectual Developmental Disorder
Myelofibrosis	Primary Myelofibrosis Agnogenic Myeloid Metaplasia Idiopathic Myelofibrosis Myeloid Metaplasia Myelofibrosis With Myeloid Metaplasia Osteomyelofibrosis Megakaryocytic Myelosclerosis Myelosclerosis Chronic Idiopathic Myelofibrosis Myelofibrosis, Idiopathic Myelofibrosis With Myeloid Metaplasia, Somatic Myelofibrosis, Somatic Aleukemic Myelosis Bone Marrow Fibrosis MYELOF MMM Agnogenic Myeloid Metaplasia With Myelofibrosis Ammm Myelosclerosis With Myeloid Metaplasia Myelofibrosis Nos
Intestinal Tuberculosis	Tuberculosis Of Intestine Tuberculosis Of Intestines
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Osteogenesis Imperfecta, Type Iv	Osteogenesis Imperfecta Type 4 Osteogenesis Imperfecta Type Iv OI4 Oi, Type Iv Osteogenesis Imperfecta With Normal Sclerae Oi Type Iv Oi Type 4 Osteogenesis Imperfecta With Normal Sclera Common Variable Oi With Normal Sclerae Osteogenesis Imperfecta 4 Oi-Iv
Patent Ductus Arteriosus 1	Patent Ductus Arteriosus PDA1 Pda Ductus Arteriosus, Patent Patent Ductus Arteriosus, Susceptibility To Patent Ductus Botalli Patency Of The Ductus Arteriosus Patent Ductus Arteriosus Familial Ductus Arteriosus Patent Patent Ductus Arteriosus - Persisting Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13355	SLCO2A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13356	SLCO2B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21259	Slco2a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27778	Slco2a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SLCO2A1	VGNC	VGNC:77600
Felis catus	SLCO2A1	VGNC	VGNC:65444
Bos taurus	SLCO2A1	VGNC	VGNC:34951
Rattus norvegicus	SLCO2A1	RGD	RGD:3051
Canis familiaris	SLCO2A1	VGNC	VGNC:46495
Mus musculus	SLCO2A1	MGD	MGI:1346021
Others	SLCO2A1	NCBI