Rpl11 - ribosomal protein L11 Gene

Also Known as 2010203J19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67025

Summary

Predicted to enable several functions, including peroxisome proliferator activated receptor binding activity; ubiquitin Ligase inhibitor activity; and ubiquitin protein Ligase binding activity. Predicted to be a structural constituent of ribosome. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and protein localization to nucleus. Located in cytoplasm and nucleolus. Is expressed in cerebral cortex. Used to study Diamond-Blackfan anemia 7. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 7 and T-cell acute lymphoblastic leukemia. Orthologous to human RPL11 (ribosomal protein L11). [provided by Alliance of Genome Resources, Apr 2022]

Rpl11 Products (1)

mRNA Protein Name
NM_025919.3 NP_080195.1 60S ribosomal protein L11

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15195100 MGI
enables structural constituent of ribosome IDA
IDA: Inferred from direct assay
36517592 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
21804542 MGI
involved in positive regulation of signal transduction by p53 class mediator IMP
IMP: Inferred from mutant phenotype
21804542 MGI
involved in protein localization to nucleus IMP
IMP: Inferred from mutant phenotype
15195100 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21804542 MGI
part of cytosolic large ribosomal subunit IDA
IDA: Inferred from direct assay
36517592 MGI
part of cytosolic large ribosomal subunit IPI
IPI: Inferred from physical interaction
36517592 MGI
located in nucleolus IDA
IDA: Inferred from direct assay
15195100 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

60S ribosomal protein L11

Rpl11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Rpl11 Q9CXW4 Mdm2 Mus musculus P23804
Anti Bait CoIP
17936560
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12162 RPL11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rpl11 NCBI NCBI:6135