Plekho1 - pleckstrin homology domain containing, family O member 1 Gene

Mus musculus

Also known as Jza2; Ckip1; CKIP-1; JZA-20; 2810052M02Rik

Gene ID: 67220 | Gene type: protein coding

About Plekho1

Summary

Acts upstream of or within several processes, including lamellipodium morphogenesis; myoblast fusion; and myoblast migration. Located in muscle cell projection membrane and ruffle membrane. Orthologous to human PLEKHO1 (pleckstrin homology domain containing O1). [provided by Alliance of Genome Resources, Apr 2022]

Plekho1 Products(1)

mRNA	Protein	Name
NM_023320.2	NP_075809.1	pleckstrin homology domain-containing family O member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22553210	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within lamellipodium morphogenesis	IDA IDA: Inferred from direct assay	22553210	MGI
acts upstream of or within lamellipodium morphogenesis	IMP IMP: Inferred from mutant phenotype	22553210	MGI
acts upstream of or within myoblast fusion	IDA IDA: Inferred from direct assay	22553210	MGI
acts upstream of or within myoblast fusion	IMP IMP: Inferred from mutant phenotype	22553210	MGI
acts upstream of or within myoblast migration	IMP IMP: Inferred from mutant phenotype	22553210	MGI
acts upstream of or within regulation of cell shape	IDA IDA: Inferred from direct assay	22553210	MGI
acts upstream of or within regulation of cell shape	IMP IMP: Inferred from mutant phenotype	22553210	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in muscle cell projection membrane	IDA IDA: Inferred from direct assay	22553210	MGI
located in ruffle membrane	IDA IDA: Inferred from direct assay	22553210	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pleckstrin homology domain-containing family O member 1

CK2 interacting protein 1	Jun zipper-associated 2
PH domain-containing family O member 1	TNF intracellular domain-interacting protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10700	PLEKHO1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Plekho1	NCBI	NCBI:51177

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