Ero1b - endoplasmic reticulum oxidoreductase 1 beta Gene

Also Known as Ero1lb; ero1-beta; 1300013B24Rik; 1700065B09Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 67475

Summary

Enables protein-disulfide reductase activity. Acts upstream of or within several processes, including cell redox homeostasis; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; and protein maturation. Located in membrane. Orthologous to human ERO1B (endoplasmic reticulum oxidoreductase 1 beta). [provided by Alliance of Genome Resources, Apr 2022]

Ero1b Products (1)

mRNA	Protein	Name
NM_026184.2	NP_080460.2	ERO1-like protein beta precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables disulfide oxidoreductase activity	IDA IDA: Inferred from direct assay	20308425	MGI
enables disulfide oxidoreductase activity	IMP IMP: Inferred from mutant phenotype	20308425	MGI
enables protein-disulfide reductase activity	IDA IDA: Inferred from direct assay	20308425	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cell redox homeostasis	IGI IGI: Inferred from genetic interaction	23589496	MGI
acts upstream of endoplasmic reticulum to Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	31184304	MGI
acts upstream of or within extracellular matrix organization	IGI IGI: Inferred from genetic interaction	22981861	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	20308425	MGI
acts upstream of or within insulin processing	IMP IMP: Inferred from mutant phenotype	20308425	MGI
involved in insulin processing	IMP IMP: Inferred from mutant phenotype	20308425	MGI
acts upstream of or within peptidyl-proline hydroxylation to 4-hydroxy-L-proline	IGI IGI: Inferred from genetic interaction	22981861	MGI
acts upstream of or within protein maturation by protein folding	IGI IGI: Inferred from genetic interaction	22981861	MGI
acts upstream of or within protein maturation by protein folding	IMP IMP: Inferred from mutant phenotype	20308425	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in endoplasmic reticulum lumen	IDA IDA: Inferred from direct assay	20308425	MGI
located in membrane	IDA IDA: Inferred from direct assay	20308425	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ERO1-like protein beta	ERO1-L-beta ERO1-like beta endoplasmic oxidoreductase 1 beta endoplasmic oxidoreductin-1-like protein B endoplasmic reticulum oxidoreductase beta endoplasmic reticulum oxidoreductin-1-like protein B oxidoreductin-1-L-beta

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04512	ERO1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ero1b	NCBI	NCBI:56605