Ttll4 - tubulin tyrosine ligase-like family, member 4 Gene

Mus musculus

Also known as mKIAA0173; 4632407P03Rik

Gene ID: 67534 | Gene type: protein coding

About Ttll4

Summary

Enables protein-glutamic acid Ligase activity and tubulin binding activity. Involved in peptidyl-glutamic acid modification. Acts upstream of or within protein polyglutamylation and regulation of blastocyst development. Located in 9+0 non-motile cilium and ciliary basal body. Orthologous to human TTLL4 (tubulin tyrosine Ligase like 4). [provided by Alliance of Genome Resources, Apr 2022]

Ttll4 Products(1)

mRNA	Protein	Name
NM_001014974.2	NP_001014974.1	tubulin monoglutamylase TTLL4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	26829768	MGI
enables protein-glutamic acid ligase activity	IDA IDA: Inferred from direct assay	17499049	MGI
enables tubulin binding	IDA IDA: Inferred from direct assay	21074048	MGI
enables tubulin-glutamic acid ligase activity	IDA IDA: Inferred from direct assay	17499049	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in peptidyl-glutamic acid modification	IDA IDA: Inferred from direct assay	26829768	MGI
acts upstream of or within protein polyglutamylation	IDA IDA: Inferred from direct assay	20530212	MGI
involved in protein polyglutamylation	IDA IDA: Inferred from direct assay	21074048	MGI
acts upstream of or within protein polyglutamylation	IMP IMP: Inferred from mutant phenotype	29593216	MGI
acts upstream of or within regulation of blastocyst development	IMP IMP: Inferred from mutant phenotype	29593216	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in 9+0 non-motile cilium	IDA IDA: Inferred from direct assay	17499049	MGI
located in ciliary basal body	IDA IDA: Inferred from direct assay	17499049	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tubulin monoglutamylase TTLL4

tubulin polyglutamylase TTLL4

polyglutamylase	protein monoglutamylase TTLL4
tubulin--tyrosine ligase-like protein 4

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15231	TTLL4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ttll4	NCBI	NCBI:9654

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