SS18 - SS18 subunit of BAF chromatin remodeling complex Gene

Also Known as SYT; SSXT; SMARCL1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6760

About SS18

Cytogenetic location: 18q11.2 Genomic coordinates (GRCh38): 18:26,016,253-26,091,219 (from NCBI)

This gene has 26 transcripts (splice variants), 212 orthologues, 2 paralogues and is associated with 73 phenotypes. Ubiquitous expression in thyroid (RPKM 26.0), adrenal (RPKM 22.3) and 25 other tissues.

Summary

Enables nuclear receptor coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Part of SWI/SNF complex. Implicated in synovial sarcoma. [provided by Alliance of Genome Resources, Apr 2022]

SS18 Products (3)

mRNA	Protein	Name
NM_001007559.3	NP_001007560.1	protein SSXT isoform 1
NM_001308201.2	NP_001295130.1	protein SSXT isoform 3
NM_005637.4	NP_005628.2	protein SSXT isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables nuclear receptor coactivator activity	IDA IDA: Inferred from direct assay	15919756	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15919756	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15919756	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of SWI/SNF complex	IDA IDA: Inferred from direct assay	29374058	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SS18 Protein Structure

SSXT

0
100
200
300
400
418 a.a.

Protein Preferred Names	Protein Names
protein SSXT	SS18, nBAF chromatin remodeling complex subunit

SS18 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SS18	Q15532	ATF2	Homo sapiens	P15336	Anti Tag CoIP	22439931
Intra	SS18	Q15532	ATF2	Homo sapiens	P15336	Anti Bait CoIP	22439931

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Sarcoma, Synovial	Synovial Sarcoma Synovialosarcoma Synovial Cell Sarcoma Sarcoma Synovial
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Synovium Cancer	Malignant Tumor Of Synovium Synovial Neoplasm
Colorado Tick Fever	Mountain Tick Fever Tick Fever, American Mountain American Mountain Fever Colorado Tick Encephalitis Colorado Tick-Borne Disease Mountain Fever American Mountain Tick Fever Colorado Tick-Borne Fever Colorado Tick Fever Virus Non-Exanthematous Tick Fever
Monophasic Synovial Sarcoma	Monophasic Sarcoma Of Synovium
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Primitive Neuroectodermal Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Ewing Family Of Tumors Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Biphasic Synovial Sarcoma	Synovial Sarcoma, Biphasic Biphasic Sarcoma Of Synovium
Spindle Cell Synovial Sarcoma	Synovial Sarcoma With Spindle Cell Components Synovial Sarcoma, Monophasic Fibrous Synovial Sarcoma, Spindle Cell
Kidney Hemangiopericytoma	Hemangiopericytoma Of Kidney Renal Hemangiopericytoma
Thymus Sarcomatoid Carcinoma	Thymic Carcinosarcoma Thymic Sarcomatoid Carcinoma
Epithelioid Malignant Peripheral Nerve Sheath Tumor	Epithelioid Mpnst Malignant Epithelioid Neoplasm Of The Peripheral Nerve Sheath
Heart Sarcoma	Cardiac Sarcoma Sarcoma Of Heart
Extraosseous Chondrosarcoma	Extraskeletal Myxoid Chondrosarcoma
Myxofibrosarcoma	Fibromyxosarcoma Fibromyxoid Sarcoma Myxoid Malignant Fibrous Histiocytoma Dermatofibrosarcoma Protuberans, Myxoid
Pericardium Cancer	Malignant Neoplasm Of Pericardium Malignant Tumor Of Pericardium Pericardial Tumor Neoplasm Of Pericardium
Chondrosarcoma, Extraskeletal Myxoid	Extraskeletal Myxoid Chondrosarcoma Emc Myxoid Extraosseous Chondrosarcoma
Cellular Schwannoma	Cellular Neurinoma
Lung Sarcoma	Pulmonary Sarcoma
Well-Differentiated Liposarcoma	Atypical Lipomatous Tumor Atypical Lipoma Alt Wdls Liposarcoma, Well Differentiated Pleomorphic Lipoma
Myoepithelial Carcinoma	Malignant Myoepithelioma Myoepithelioma Carcinoma
Myxoid Liposarcoma	Myxoid/Round Cell Liposarcoma Liposarcoma, Myxoid Mrcls Myxoliposarcoma MXLIPO Liposarcoma Myxoid Liposarcoma
Spindle Cell Thymoma	Medullary Thymoma Thymoma, Medullary Thymoma, Type A
Pleomorphic Liposarcoma	Pls Liposarcoma Pleomorphic Liposarcoma, Pleomorphic
Dedifferentiated Liposarcoma	Ddls Liposarcoma Dedifferentiated Liposarcoma, Dedifferentiated
Synovium Neoplasm	Synovial Neoplasm Tumor Of Synovium
Spindle Cell Sarcoma	Sarcoma Sarcoma Spindle Cell Sarcoma, Spindle Cell Sarcoma - Category
Conventional Leiomyosarcoma
Kidney Sarcoma	Renal Sarcoma Sarcoma Of Kidney
Cellular Myxoid Liposarcoma	Round Cell Liposarcoma
Clear Cell Sarcoma	Sarcoma, Clear Cell Adult Soft Part Clear Cell Sarcoma Clear Cell Sarcoma Of Soft Parts Malignant Melanoma Of Soft Parts Malignant Melanoma Of Soft Tissues Melanoma, Malignant, Of Soft Parts Sarcoma Clear Cell
Alveolar Soft Part Sarcoma	ASPS Alveolar Soft-Part Sarcoma Sarcoma, Alveolar Soft Part Alveolar Soft Tissue Sarcoma Sarcoma Alveolar Soft Part Adult Alveolar Soft-Part Sarcoma Childhood Alveolar Soft-Part Sarcoma
Epithelioid Cell Synovial Sarcoma	Synovial Sarcoma, Epithelioid Cell Epithelioid Synovial Sarcoma
Ossifying Fibromyxoid Tumor	Ossifying Fibromyxoid Tumour Ossifying Fibromyxoma
Heart Cancer	Malignant Neoplasm Of Heart Heart Neoplasm Cardiac Tumor Malignant Cardiac Tumor Tumour Of Heart Heart Neoplasms Cardiac Carcinoma
Desmoplastic Small Round Cell Tumor	Dsrct Desmoplastic Small Round-Cell Tumor Desmoplastic Small Round-Cell Neoplasm
Spindle Cell Rhabdomyosarcoma
Malignant Triton Tumor	Malignant Peripheral Nerve Sheath Neoplasm With Rhabdomyosarcoma Malignant Triton Tumour Mpnst With Rhabdomyoblastic Differentiation Mpnst With Rhabdomyosarcoma Mpnst With Rhabdomyosarcomatous Differentiation Mtt Malignant Peripheral Nerve Sheath Tumor With Rhabdomyosarcomatous Differenciation Malignant Peripheral Nerve Sheath Tumor With Rhabdomyoblastic Differentiation
Epithelioid Sarcoma	Epithelioid Cell Sarcoma Sarcoma Epithelioid Sarcoma, Epithelioid
Skeletal Muscle Cancer	Malignant Tumor Of Skeletal Muscle Skeletal Muscle Neoplasm
Rhabdoid Cancer	Rhabdoid Tumor Malignant Rhabdoid Tumor Malignant Rhabdoid Tumour Rhabdoid Sarcoma Rhabdoid Tumor Predisposition Syndrome 1 Rhabdoid Tumor Predisposition Syndrome 2 Atypical Teratoid Rhabdoid Tumor Brain Tumor, Posterior Fossa, Of Infancy, Familial Atypical Teratoid/Rhabdoid Tumor
Meninges Sarcoma	Meningeal Sarcoma Sarcoma Of Meninges Meningothelial Sarcoma Leptomeningeal Sarcoma
Sarcomatoid Mesothelioma	Malignant Fibrous Mesothelioma Spindled Mesothelioma
Muscle Cancer	Myosarcoma Malignant Neoplasm Of Muscle Malignant Tumor Of Muscle Malignant Tumor Of The Muscle Muscle Neoplasms Myomatous Neoplasm
Mesenchymal Cell Neoplasm	Benign Miscellaneous Mesenchymal Tumor Mesenchymal Tumor Mesenchymal Tumors
Dermatofibrosarcoma Protuberans	DFSP Dermatofibrosarcoma Giant Cell Fibroblastoma Metastatic Dermatofibrosarcoma Protuberans Familial Dermatofibrosarcoma Protuberans Darier-Ferrand Tumor Darier-Hoffmann Tumor
Kidney Cortex Disease
Pseudosarcomatous Fibromatosis	Nodular Fasciitis Pseudosarcomatous Fasciitis Fasciitis - Nodular Fasciitis Nodular
Congenital Fibrosarcoma	Infantile Fibrosarcoma
Rhabdomyosarcoma 2	Alveolar Rhabdomyosarcoma Rhabdomyosarcoma, Alveolar Rhabdomyosarcoma Alveolar RMS2 Rmsa Rhabdomyosarcoma 2, Alveolar Alveolar Childhood Rhabdomyosarcoma Arms Rhabdomyosarcoma, Type 2
Inflammatory Myofibroblastic Tumor	Inflammatory Fibrosarcoma
Bone Osteosarcoma	Osteosarcoma Of Bone Primary Osteosarcoma Of Bone
Neurilemmomatosis	Schwannomatosis Neurofibromatosis Type 3 Nf3 Neurilemmomatosis Congenital Cutaneous Neurinomatosis Congenital Cutaneous Neurilemmomatosis Multiple Neurilemmomas Multiple Schwannomas Neurilemmomatosis, Congenital Cutaneous Schwannomatosis 1 Neurofibromatosis 3 Mixed Central And Peripheral Neurofibromatosis Nf3 - [Neurofibromatosis Type 3]
Embryonal Rhabdomyosarcoma	Rhabdomyosarcoma, Embryonal Rhabdomyosarcoma Embryonal Botryoid Rhabdomyosarcoma Erms Spindle Cell Rhabdomyosarcomas
Endometrial Stromal Sarcoma	Ess Endometrial Stromal Sarcoma, High Grade Undifferentiated Endometrial Sarcoma Stromal Sarcoma Of The Corpus Uteri Sarcoma Endometrial Stromal Sarcoma, Endometrial Stromal Undifferentiated Stromal Sarcoma
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148739	dBRD 9-A		99.50%	Unkown
HY-RS13802	SS18 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13803	SS18L2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19385	Ss18 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25877	Ss18 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SS18	VGNC	VGNC:65698
Bos taurus	SS18	VGNC	VGNC:35305
Rattus norvegicus	SS18	RGD	RGD:1311919
Mus musculus	SS18	MGD	MGI:107708
Canis familiaris	SS18	VGNC	VGNC:46823
Macaca mulatta	SS18	VGNC	VGNC:77896
Others	SS18	NCBI