Alkbh8 - alkB homolog 8, tRNA methyltransferase Gene

Also Known as Abh8; 4930562C03Rik; 8030431D03Rik; 9430088N01Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67667

Summary

Enables 2-oxoglutarate-dependent dioxygenase activity; catalytic activity, acting on a tRNA; and iron ion binding activity. Involved in tRNA methylation and tRNA wobble uridine modification. Predicted to be located in cytosol and nuclear body. Predicted to be active in cytoplasm and nucleus. Is expressed in nervous system and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human ALKBH8 (alkB homolog 8, tRNA methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Alkbh8 Products (4)

mRNA Protein Name
NM_001405036.1 NP_001391965.1 alkylated DNA repair protein alkB homolog 8 isoform 1
NM_001405037.1 NP_001391966.1 alkylated DNA repair protein alkB homolog 8 isoform 2
NM_001405038.1 NP_001391967.1 alkylated DNA repair protein alkB homolog 8 isoform 3
NM_026303.2 NP_080579.1 alkylated DNA repair protein alkB homolog 8 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables iron ion binding IDA
IDA: Inferred from direct assay
20583019 MGI
enables tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity IDA
IDA: Inferred from direct assay
20583019 MGI
enables tRNA (uridine) methyltransferase activity IMP
IMP: Inferred from mutant phenotype
20123966 MGI
Biological Process GO Annotation Evidence References Source
involved in tRNA methylation IMP
IMP: Inferred from mutant phenotype
20123966 MGI
involved in tRNA wobble uridine modification IDA
IDA: Inferred from direct assay
20583019 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alkylated DNA repair protein alkB homolog 8

  • S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8

  • alkB, alkylation repair homolog 8

  • probable alpha-ketoglutarate-dependent dioxygenase ABH8

  • tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-153100A (S)-mchm5U 98.87% Unkown
HY-RS00609 ALKBH8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Alkbh8 NCBI NCBI:91801