Tmem100 - transmembrane protein 100 Gene

Also Known as 1810057C19Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 67888

Summary

Involved in positive regulation of endothelial cell differentiation; positive regulation of vasculogenesis; and regulation of sensory perception of pain. Acts upstream of or within several processes, including circulatory system development; protein kinase B signaling; and regulation of calcium-mediated signaling. Located in perikaryon; perinuclear region of cytoplasm; and plasma membrane. Is expressed in several structures, including cardiovascular system; eye; genitourinary system; hemolymphoid system gland; and spinal cord. Orthologous to human TMEM100 (transmembrane protein 100). [provided by Alliance of Genome Resources, Apr 2022]

Tmem100 Products (1)

mRNA	Protein	Name
NM_026433.2	NP_080709.1	transmembrane protein 100

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25640077	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	22783020	MGI
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	22783020	MGI
acts upstream of or within arterial endothelial cell differentiation	IMP IMP: Inferred from mutant phenotype	22783020	MGI
acts upstream of or within endocardial cushion development	IMP IMP: Inferred from mutant phenotype	25318679	MGI
acts upstream of or within epithelial to mesenchymal transition involved in endocardial cushion formation	IMP IMP: Inferred from mutant phenotype	25318679	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	20848592	MGI
involved in positive regulation of endothelial cell differentiation	IMP IMP: Inferred from mutant phenotype	22783020	MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	22783020	MGI
involved in positive regulation of vasculogenesis	IMP IMP: Inferred from mutant phenotype	22783020	MGI
acts upstream of or within regulation of calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	25318679	MGI
involved in regulation of sensory perception of pain	IMP IMP: Inferred from mutant phenotype	25640077	MGI
acts upstream of or within vasculogenesis	IMP IMP: Inferred from mutant phenotype	22783020	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in perikaryon	IDA IDA: Inferred from direct assay	23485812	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	22783020	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	23485812	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transmembrane protein 100

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10356	T100-Mut	Inhibitor	/	Unkown
HY-RS14643	TMEM100 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tmem100	NCBI	NCBI:55273