Hormad1 - HORMA domain containing 1 Gene

Also Known as Nohma; 4921522K05Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 67981

Summary

Involved in several processes, including gamete generation; meiotic chromosome segregation; and regulation of cell cycle process. Acts upstream of or within homologous chromosome pairing at meiosis. Located in cytoplasm and synaptonemal complex. Is expressed in gonad. Orthologous to human HORMAD1 (HORMA domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Hormad1 Products (5)

mRNA	Protein	Name
NM_001289532.1	NP_001276461.1	HORMA domain-containing protein 1 isoform a
NM_001289534.1	NP_001276463.1	HORMA domain-containing protein 1 isoform b
NM_001289537.1	NP_001276466.1	HORMA domain-containing protein 1 isoform b
NM_001373886.1	NP_001360815.1	HORMA domain-containing protein 1 isoform a
NM_026489.3	NP_080765.1	HORMA domain-containing protein 1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22549958	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in blastocyst development	IMP IMP: Inferred from mutant phenotype	21079677	MGI
acts upstream of or within homologous chromosome pairing at meiosis	IMP IMP: Inferred from mutant phenotype	22530760	MGI
involved in meiotic DNA double-strand break formation	IMP IMP: Inferred from mutant phenotype	21079677	MGI
involved in meiotic cell cycle	IEP IEP: Inferred from expression pattern	19686734	MGI
acts upstream of or within meiotic recombination checkpoint signaling	IMP IMP: Inferred from mutant phenotype	22530760	MGI
involved in meiotic recombination checkpoint signaling	IMP IMP: Inferred from mutant phenotype	21079677	MGI
involved in meiotic sister chromatid cohesion	IMP IMP: Inferred from mutant phenotype	21079677	MGI
involved in oogenesis	IMP IMP: Inferred from mutant phenotype	21079677	MGI
involved in regulation of homologous chromosome segregation	IMP IMP: Inferred from mutant phenotype	21079677	MGI
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	21079677	MGI
involved in synaptonemal complex assembly	IMP IMP: Inferred from mutant phenotype	21478856	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in chromosome	IDA IDA: Inferred from direct assay	19686734	MGI
located in condensed nuclear chromosome	IDA IDA: Inferred from direct assay	22164254	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	19686734	MGI
located in nucleus	IDA IDA: Inferred from direct assay	19686734	MGI
located in synaptonemal complex	IDA IDA: Inferred from direct assay	22854038	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
HORMA domain-containing protein 1	HORMA domain containing protein newborn ovary HORMA protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06291	HORMAD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hormad1	NCBI	NCBI:84072