HORMAD1 - HORMA domain containing 1 Gene

Also Known as CT46; NOHMA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84072

About HORMAD1

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:150,698,060-150,720,895 (from NCBI)

This gene has 8 transcripts (splice variants), 206 orthologues and 1 paralogue. Restricted expression toward testis (RPKM 50.3).

Summary

This gene encodes a HORMA domain-containing protein. HORMA domains are involved in chromatin binding and play a role in cell cycle regulation. The encoded protein may play a role in meiosis, and expression of this gene is a potential marker for Cancer. A pseudogene of this gene is located on the long arm of chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

HORMAD1 Products (2)

mRNA Protein Name
NM_001199829.2 NP_001186758.1 HORMA domain-containing protein 1 isoform 2
NM_032132.5 NP_115508.2 HORMA domain-containing protein 1 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HORMAD1 Protein Structure

HORMA

HORMA: HORMA domain (22 - 220)

  • 0
  • 100
  • 200
  • 300
  • 394 a.a.
Protein Preferred Names Protein Names

HORMA domain-containing protein 1

  • cancer/testis antigen 46

HORMAD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HORMAD1 Q86X24 DCDC2 Homo sapiens Q9UHG0
Validated Y2H
32296183
Intra
HORMAD1 Q86X24 DCDC2 Homo sapiens Q9UHG0
Y2H Prey Pooling
32296183
Intra
HORMAD1 Q86X24 DCDC2 Homo sapiens Q9UHG0
Y2H Array
32296183
Intra
HORMAD1 Q86X24 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
HORMAD1 Q86X24 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
HORMAD1 Q86X24 MYG1 Homo sapiens Q9HB07
Y2H Array
32296183
Intra
HORMAD1 Q86X24 MYG1 Homo sapiens Q9HB07
Y2H Prey Pooling
32296183
Intra
HORMAD1 Q86X24 MYG1 Homo sapiens Q9HB07
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Male Infertility

  • Infertility, Male

  • Infertility Male

  • Male Sterility

  • Absolute Infertility
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Fanconi Anemia, Complementation Group A

  • Fanconi Anemia

  • Fanconi Pancytopenia

  • Fanconi Anemia Complementation Group A

  • FANCA

  • Fa

  • Fanconi Panmyelopathy

  • Fanconi'S Anemia

  • Fanconi Anaemia

  • Fanconi'S Anaemia

  • Fanconi Hypoplastic Anemia

  • Estren-Dameshek Variant Of Fanconi Anemia

  • Estren-Dameshek Variant Of Fanconi Pancytopenia

  • Fanconi Anemia Estren-Dameshek Variant

  • Fanconis Anemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06291 HORMAD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta HORMAD1 VGNC VGNC:97775
Bos taurus HORMAD1 VGNC VGNC:55235
Rattus norvegicus HORMAD1 RGD RGD:1564960
Canis familiaris HORMAD1 VGNC VGNC:103682
Mus musculus HORMAD1 MGD MGI:1915231
Felis catus HORMAD1 VGNC VGNC:107556
Others HORMAD1 NCBI