Dusp19 - dual specificity phosphatase 19 Gene

Also Known as SKRP1; TS-DSP1; 5930436K22Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 68082

Summary

Enables several functions, including phosphoprotein Phosphatase activity; protein kinase binding activity; and protein kinase regulator activity. Involved in negative regulation of JUN kinase activity; positive regulation of JNK cascade; and positive regulation of JUN kinase activity. Acts upstream of or within JNK cascade; negative regulation of MAPK cascade; and protein dephosphorylation. Located in cytoplasm. Orthologous to human DUSP19 (dual specificity Phosphatase 19). [provided by Alliance of Genome Resources, Apr 2022]

Dusp19 Products (1)

mRNA	Protein	Name
NM_024438.4	NP_077758.1	dual specificity protein phosphatase 19

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables JUN kinase phosphatase activity	IDA IDA: Inferred from direct assay	11959861	MGI
enables MAP-kinase scaffold activity	IDA IDA: Inferred from direct assay	11959862	MGI
enables mitogen-activated protein kinase kinase binding	IPI IPI: Inferred from physical interaction	11959862	MGI
enables mitogen-activated protein kinase kinase kinase binding	IPI IPI: Inferred from physical interaction	11959862	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11959861	MGI
enables protein kinase activator activity	IDA IDA: Inferred from direct assay	11959862	MGI
enables protein kinase inhibitor activity	IDA IDA: Inferred from direct assay	11959862	MGI
enables protein tyrosine/serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	11432789	MGI
enables protein tyrosine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	11959861	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within JNK cascade	IDA IDA: Inferred from direct assay	11959862	MGI
involved in negative regulation of JNK cascade	IDA IDA: Inferred from direct assay	11959862	MGI
involved in negative regulation of JUN kinase activity	IDA IDA: Inferred from direct assay	11959862	MGI
acts upstream of or within negative regulation of MAPK cascade	IDA IDA: Inferred from direct assay	11959861	MGI
involved in negative regulation of protein kinase activity	IDA IDA: Inferred from direct assay	11959862	MGI
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	11959862	MGI
involved in positive regulation of JUN kinase activity	IDA IDA: Inferred from direct assay	11959862	MGI
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	11959862	MGI
involved in positive regulation of protein kinase activity	IDA IDA: Inferred from direct assay	11959862	MGI
acts upstream of or within protein dephosphorylation	IDA IDA: Inferred from direct assay	11959861	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11959861	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
dual specificity protein phosphatase 19	protein phosphatase SKRP1 stress-activated protein kinase pathway-regulating phosphatase 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04059	DUSP19 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dusp19	NCBI	NCBI:142679