DUSP19 - dual specificity phosphatase 19 Gene

Also Known as SKRP1; DUSP17; LMWDSP3; TS-DSP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 142679

About DUSP19

Cytogenetic location: 2q32.1 Genomic coordinates (GRCh38): 2:183,078,747-183,100,008 (from NCBI)

This gene has 3 transcripts (splice variants), 264 orthologues and 30 paralogues. Low expression observed in reference dataset.

Summary

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine Phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase Phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

DUSP19 Products (3)

mRNA Protein Name
NM_001142314.2 NP_001135786.1 dual specificity protein phosphatase 19 isoform 2
NM_001321519.2 NP_001308448.1 dual specificity protein phosphatase 19 isoform 3
NM_080876.4 NP_543152.1 dual specificity protein phosphatase 19 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21516116 GOA
enables protein tyrosine/serine/threonine phosphatase activity IDA
IDA: Inferred from direct assay
12479873 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DUSP19 Protein Structure

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (74 - 202)

  • 0
  • 100
  • 200
  • 217 a.a.
Protein Preferred Names Protein Names

dual specificity protein phosphatase 19

  • SAPK pathway-regulating phosphatase 1

DUSP19 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DUSP19 Q8WTR2 ACTB Homo sapiens P60709
Anti Tag CoIP
28514442
Intra
DUSP19 Q8WTR2 ALAS1 Homo sapiens P13196
Anti Tag CoIP
33961781
Intra
DUSP19 Q8WTR2 ALAS1 Homo sapiens P13196
Validated Y2H
25416956
Intra
DUSP19 Q8WTR2 ALAS1 Homo sapiens P13196
Y2H Array
32296183
Intra
DUSP19 Q8WTR2 ALAS1 Homo sapiens P13196
Anti Tag CoIP
28514442
Intra
DUSP19 Q8WTR2 ALAS1 Homo sapiens P13196
Y2H Array
25416956
Intra
DUSP19 Q8WTR2 ALAS1 Homo sapiens P13196
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ichthyosis, Congenital, Autosomal Recessive 4b

  • Harlequin Ichthyosis

  • Autosomal Recessive Congenital Ichthyosis 4b

  • Hi

  • Harlequin Fetus

  • ARCI4B

  • Ichthyosis Congenita, Harlequin Fetus Type

  • Harlequin Type Ichthyosis

  • 'Harlequin Fetus'

  • Harlequin Type Ichthyosis Congenita

  • Harlequin Type Ichthyosis Fetalis

  • Harlequin Baby Syndrome

  • Ichthyosis Congenita, Harlequin Type

  • Ichthyosis Fetalis, Harlequin Type

  • Ichthyosis Congenita Harlequin Fetus Type

  • Ichthyosis, Harlequin

  • Ichthyosis, Congenital, Autosomal Recessive, Type 4b
Myoclonic Epilepsy Of Lafora

  • Lafora Disease

  • Epilepsy, Progressive Myoclonic 2b

  • EPM2

  • Melf

  • Epilepsy, Progressive Myoclonic 2a

  • Epm2a

  • Lafora'S Disease

  • Lafora Body Disease

  • Lbd

  • Epilepsy, Progressive Myoclonic, 2a

  • Lafora Progressive Myoclonic Epilepsy

  • Epilepsy Progressive Myoclonic 2

  • Lafora Body Disorder

  • Pme Type 2

  • Progressive Myoclonic Epilepsy Type 2

  • Progressive Myoclonus Epilepsy Type 2

  • Epilepsy, Progressive Myoclonic 2

  • Epm2b

  • Ld

  • Progressive Myoclonic Epilepsy 2

  • Progressive Myoclonic Epilepsy 2a

  • Progressive Myoclonic Epilepsy 2b

  • Progressive Myoclonic Epilepsy Lafora Type

  • Epilepsy, Myoclonic, Of Lafora
Cowden Syndrome

  • Cowden Disease

  • Multiple Hamartoma Syndrome

  • Cowden'S Disease

  • Lhermitte-Duclos Disease

  • Cd

  • Cs

  • Mham

  • Dysplastic Gangliocytoma Of Cerebellum

  • Cowden'S Syndrome

  • Hamartoma Syndrome, Multiple
Skin Disease

  • Skin Diseases

  • Genodermatosis

  • Abnormality Of The Skin

  • Skin Diseases, Genetic

  • Skin And Subcutaneous Tissue Disease

  • Dermatologic Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04059 DUSP19 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DUSP19 VGNC VGNC:61665
Canis familiaris DUSP19 VGNC VGNC:40131
Bos taurus DUSP19 VGNC VGNC:28254
Mus musculus DUSP19 MGD MGI:1915332
Rattus norvegicus DUSP19 RGD RGD:1307457
Macaca mulatta DUSP19 VGNC VGNC:99357
Others DUSP19 NCBI