RP1 - Rp1 RP1, axonemal microtubule associated Gene

Also Known as Rp1h; RGD1560182

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 681377

Summary

This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains, which bind microtubules and regulate microtubule polymerization. The encoded protein is a photoreceptor microtubule-associated protein and is required for correct stacking of outer segment disc. This protein and the RP1L1 protein, another retinal-specific protein, play essential and synergistic roles in affecting photosensitivity and outer segment morphogenesis of rod photoreceptors. Because of its response to in vivo retinal oxygen levels, this protein was initially named ORP1 (oxygen-regulated protein-1). This protein was subsequently designated RP1 (retinitis pigmentosa 1) when it was found that mutations in this gene cause autosomal dominant retinitis pigmentosa. Mutations in this gene also cause autosomal recessive retinitis pigmentosa. [provided by RefSeq, Sep 2010]

RP1 Products (1)

mRNA Protein Name
NM_001195676.1 NP_001182605.1 oxygen-regulated protein 1
Protein Preferred Names Protein Names

oxygen-regulated protein 1

  • lipoxygenase homology domain-containing protein 1

  • rCG30348-like

  • retinitis pigmentosa 1 (autosomal dominant)

  • retinitis pigmentosa 1 homolog

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P5565 RP-1 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N9182 Zeaxanthin dipalmitate Inducer 99.9% Unkown
HY-175671 LSD1/HDAC-IN-3 Inhibitor / Unkown
HY-N16873 Pseudoginsenoside RP1 / Unkown
HY-RS08138 MAPRE2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12138 RP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12139 RP1L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13926 STK19 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17362 Rp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21056 Stk19 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23816 Rp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24351 Cyld Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens RP1 NCBI NCBI:6101
Canis familiaris RP1 NCBI NCBI:403565
Macaca fascicularis RP1 NCBI NCBI:102146237
Canis lupus familiaris RP1 NCBI
Mus musculus RP1 NCBI NCBI:19888