Ndnf - neuron-derived neurotrophic factor Gene

Also Known as epidermacan; A930038C07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 68169

Summary

Enables heparin binding activity. Involved in gonadotrophin-releasing hormone neuronal migration to the hypothalamus; response to ischemia; and vascular wound healing. Acts upstream of or within extracellular matrix organization; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan; and positive regulation of cell-substrate adhesion. Located in extracellular matrix. Is expressed in several structures, including brain; embryo mesenchyme; intervertebral disc; lung; and molar. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism. Orthologous to human NDNF (neuron derived neurotrophic factor). [provided by Alliance of Genome Resources, Apr 2022]

Ndnf Products (1)

mRNA Protein Name
NM_172399.3 NP_765987.2 protein NDNF precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glycosaminoglycan binding IDA
IDA: Inferred from direct assay
18757743 MGI
enables heparin binding IDA
IDA: Inferred from direct assay
18757743 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within extracellular matrix organization IDA
IDA: Inferred from direct assay
18757743 MGI
involved in gonadotrophin-releasing hormone neuronal migration to the hypothalamus IMP
IMP: Inferred from mutant phenotype
31883645 MGI
acts upstream of or within positive regulation of cell-substrate adhesion IDA
IDA: Inferred from direct assay
18757743 MGI
involved in response to ischemia IDA
IDA: Inferred from direct assay
24706764 MGI
involved in vascular wound healing IMP
IMP: Inferred from mutant phenotype
24706764 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular matrix IDA
IDA: Inferred from direct assay
18757743 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein NDNF

  • fibronectin type-III domain-containing protein C4orf31 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09111 NDNF Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ndnf NCBI NCBI:79625